4-(1-benzyloxycarbonyl-3-methyl-butylcarbamoyl)-2'-(3-carbamoyl-phenylcarbamoyl)-biphenyl-2-carboxylic acid tert-butyl ester

Base Information

Chemical Name:4-(1-benzyloxycarbonyl-3-methyl-butylcarbamoyl)-2'-(3-carbamoyl-phenylcarbamoyl)-biphenyl-2-carboxylic acid tert-butyl ester
CAS No.:917114-03-5
Molecular Formula:C₃₉H₄₁N₃O₇
Molecular Weight:663.77
Hs Code.:

4-(1-benzyloxycarbonyl-3-methyl-butylcarbamoyl)-2'-(3-carbamoyl-phenylcarbamoyl)-biphenyl-2-carboxylic acid <i>tert</i>-butyl ester

Synonyms:4-(1-benzyloxycarbonyl-3-methyl-butylcarbamoyl)-2'-(3-carbamoyl-phenylcarbamoyl)-biphenyl-2-carboxylic acid tert-butyl ester

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Chemical Property of 4-(1-benzyloxycarbonyl-3-methyl-butylcarbamoyl)-2'-(3-carbamoyl-phenylcarbamoyl)-biphenyl-2-carboxylic acid tert-butyl ester

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Technology Process of 4-(1-benzyloxycarbonyl-3-methyl-butylcarbamoyl)-2'-(3-carbamoyl-phenylcarbamoyl)-biphenyl-2-carboxylic acid tert-butyl ester

There total 8 articles about 4-(1-benzyloxycarbonyl-3-methyl-butylcarbamoyl)-2'-(3-carbamoyl-phenylcarbamoyl)-biphenyl-2-carboxylic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 576170-38-2
3-(tert-butyl) 1-methyl 4-hydroxyisophthalate

: 917114-03-5
4-(1-benzyloxycarbonyl-3-methyl-butylcarbamoyl)-2'-(3-carbamoyl-phenylcarbamoyl)-biphenyl-2-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 13.3 g / pyridine / CH₂Cl₂ / 0.5 h / 20 °C

2: 4.19 g / K₃PO₄ / Pd(PPh₃)4 / dimethylformamide / 3 h / 100 °C

3: 3.75 g / sodium chlorite; NaH₂PO₄; 2-methyl-2-butene / 2-methyl-propan-2-ol; H₂O; acetonitrile / 12 h / 20 °C

4: 2.29 g / 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride; 1-hydroxybenzotriazole / dimethylformamide / 12 h / 60 °C

5: 1.87 g / NaOH / ethanol; H₂O / 12 h / 20 °C

6: 0.200 g / 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride / dimethylformamide / 12 h / 20 °C

With pyridine; sodium hydroxide; sodium chlorite; potassium phosphate; sodium dihydrogenphosphate; 2-methyl-but-2-ene; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In ethanol; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile; tert-butyl alcohol; 2: Suzuki coupling;
DOI:10.1016/j.bmc.2006.09.071

Reference yield:

: 790230-23-8
3-tert-butyl 1-methyl 4-{[(trifluoromethyl)sulfonyl]oxy}isophthalate

: 917114-03-5
4-(1-benzyloxycarbonyl-3-methyl-butylcarbamoyl)-2'-(3-carbamoyl-phenylcarbamoyl)-biphenyl-2-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 4.19 g / K₃PO₄ / Pd(PPh₃)4 / dimethylformamide / 3 h / 100 °C

2: 3.75 g / sodium chlorite; NaH₂PO₄; 2-methyl-2-butene / 2-methyl-propan-2-ol; H₂O; acetonitrile / 12 h / 20 °C

3: 2.29 g / 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride; 1-hydroxybenzotriazole / dimethylformamide / 12 h / 60 °C

4: 1.87 g / NaOH / ethanol; H₂O / 12 h / 20 °C

5: 0.200 g / 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride / dimethylformamide / 12 h / 20 °C

With sodium hydroxide; sodium chlorite; potassium phosphate; sodium dihydrogenphosphate; 2-methyl-but-2-ene; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In ethanol; water; N,N-dimethyl-formamide; acetonitrile; tert-butyl alcohol; 1: Suzuki coupling;
DOI:10.1016/j.bmc.2006.09.071

Reference yield:

: 79128-78-2
2-hydroxy-5-(methoxycarbonyl)benzoic acid

: 917114-03-5
4-(1-benzyloxycarbonyl-3-methyl-butylcarbamoyl)-2'-(3-carbamoyl-phenylcarbamoyl)-biphenyl-2-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: MgSO₄; H₂SO₄ / CH₂Cl₂ / 12 h / 20 °C

2: 13.3 g / pyridine / CH₂Cl₂ / 0.5 h / 20 °C

3: 4.19 g / K₃PO₄ / Pd(PPh₃)4 / dimethylformamide / 3 h / 100 °C

4: 3.75 g / sodium chlorite; NaH₂PO₄; 2-methyl-2-butene / 2-methyl-propan-2-ol; H₂O; acetonitrile / 12 h / 20 °C

5: 2.29 g / 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride; 1-hydroxybenzotriazole / dimethylformamide / 12 h / 60 °C

6: 1.87 g / NaOH / ethanol; H₂O / 12 h / 20 °C

7: 0.200 g / 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride / dimethylformamide / 12 h / 20 °C

With pyridine; sodium hydroxide; sodium chlorite; potassium phosphate; sodium dihydrogenphosphate; 2-methyl-but-2-ene; sulfuric acid; magnesium sulfate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In ethanol; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile; tert-butyl alcohol; 3: Suzuki coupling;
DOI:10.1016/j.bmc.2006.09.071