cis-4(R)-(6-Carboxyhex-1-enyl)-2(R)-phenylthiazolidine-3-carboxylic acid tert-butyl ester

Base Information

Chemical Name:cis-4(R)-(6-Carboxyhex-1-enyl)-2(R)-phenylthiazolidine-3-carboxylic acid tert-butyl ester
CAS No.:157020-35-4
Molecular Formula:C₂₁H₂₉NO₄S
Molecular Weight:391.532
Hs Code.:

Synonyms:cis-4(R)-(6-Carboxyhex-1-enyl)-2(R)-phenylthiazolidine-3-carboxylic acid tert-butyl ester

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Chemical Property of cis-4(R)-(6-Carboxyhex-1-enyl)-2(R)-phenylthiazolidine-3-carboxylic acid tert-butyl ester

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Technology Process of cis-4(R)-(6-Carboxyhex-1-enyl)-2(R)-phenylthiazolidine-3-carboxylic acid tert-butyl ester

There total 8 articles about cis-4(R)-(6-Carboxyhex-1-enyl)-2(R)-phenylthiazolidine-3-carboxylic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 50889-29-7
(5-carboxypentyl)triphenylphosphonium bromide

: 157020-34-3
(2R,4R)-4-formyl-2-phenylthiazolidine-3-carboxylic acid tert-butyl ester

: 157020-35-4
cis-4(R)-(6-Carboxyhex-1-enyl)-2(R)-phenylthiazolidine-3-carboxylic acid tert-butyl ester

Guidance literature:: With lithium diisopropyl amide; In tetrahydrofuran; for 1h; Ambient temperature;
DOI:10.1016/S0040-4039(00)77187-5

Reference yield:

: 196930-46-8
(4R)-2-phenyl-1,3-thiazolidine-4-carboxylic acid

: 157020-35-4
cis-4(R)-(6-Carboxyhex-1-enyl)-2(R)-phenylthiazolidine-3-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 82 percent / aq. NaOH / dioxane / 0.5 h / 0 °C

3: diisobutylaluminum hydride / toluene

4: 78 percent / LDA / tetrahydrofuran; hexane / 1.) room temp., 30 min, 2.) room temp, 1 h

With sodium hydroxide; diisobutylaluminium hydride; lithium diisopropyl amide; In tetrahydrofuran; 1,4-dioxane; hexane; toluene;
DOI:10.1021/jo00107a009

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 157020-35-4
cis-4(R)-(6-Carboxyhex-1-enyl)-2(R)-phenylthiazolidine-3-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 82 percent / aq. NaOH / dioxane / 0.5 h / 0 °C

3: diisobutylaluminum hydride / toluene

4: 78 percent / LDA / tetrahydrofuran; hexane / 1.) room temp., 30 min, 2.) room temp, 1 h

With sodium hydroxide; diisobutylaluminium hydride; lithium diisopropyl amide; In tetrahydrofuran; 1,4-dioxane; hexane; toluene;
DOI:10.1021/jo00107a009