N-(2-fluoro-3-(4-methoxybutoxy)phenyl)methyl-benzothiazole-6-carboxamide

Base Information

Chemical Name:N-(2-fluoro-3-(4-methoxybutoxy)phenyl)methyl-benzothiazole-6-carboxamide
CAS No.:1202182-81-7
Molecular Formula:C₂₀H₂₁FN₂O₃S
Molecular Weight:388.463
Hs Code.:

Synonyms:N-(2-fluoro-3-(4-methoxybutoxy)phenyl)methyl-benzothiazole-6-carboxamide

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Chemical Property of N-(2-fluoro-3-(4-methoxybutoxy)phenyl)methyl-benzothiazole-6-carboxamide

Chemical Property:

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Technology Process of N-(2-fluoro-3-(4-methoxybutoxy)phenyl)methyl-benzothiazole-6-carboxamide

There total 8 articles about N-(2-fluoro-3-(4-methoxybutoxy)phenyl)methyl-benzothiazole-6-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 4-methoxybutyl methanesulfonate

: 1060782-57-1
N-(2-fluoro-3-hydroxyphenyl)methyl-benzothiazole-6-carboxamide

: 1202182-81-7
N-(2-fluoro-3-(4-methoxybutoxy)phenyl)methyl-benzothiazole-6-carboxamide

Guidance literature:: With caesium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 4h;

Reference yield:

: 1143571-79-2
2-fluoro-3-methoxybenzaldehyde oxime

: 1202182-81-7
N-(2-fluoro-3-(4-methoxybutoxy)phenyl)methyl-benzothiazole-6-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1: hydrogenchloride; hydrogen / palladium 10% on activated carbon / ethanol; water / 3 h / 20 °C / 760.05 Torr

2: hydrogen bromide / water / 5 h / Reflux

3: (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine / N,N-dimethyl-formamide / 0.5 h / 20 °C

4: caesium carbonate / N,N-dimethyl-formamide / 4 h / 20 °C

With hydrogenchloride; hydrogen bromide; hydrogen; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; caesium carbonate; triethylamine; palladium 10% on activated carbon; In ethanol; water; N,N-dimethyl-formamide;

Reference yield:

: 103438-88-6
2-fluoro-3-methoxybenzaldehyde

: 1202182-81-7
N-(2-fluoro-3-(4-methoxybutoxy)phenyl)methyl-benzothiazole-6-carboxamide

Guidance literature:: Multi-step reaction with 5 steps

1: pyridine; hydroxylamine hydrochloride / tetrahydrofuran; water / 20 °C / Cooling with ice

2: hydrogenchloride; hydrogen / palladium 10% on activated carbon / ethanol; water / 3 h / 20 °C / 760.05 Torr

3: hydrogen bromide / water / 5 h / Reflux

4: (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine / N,N-dimethyl-formamide / 0.5 h / 20 °C

5: caesium carbonate / N,N-dimethyl-formamide / 4 h / 20 °C

With pyridine; hydrogenchloride; hydroxylamine hydrochloride; hydrogen bromide; hydrogen; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; caesium carbonate; triethylamine; palladium 10% on activated carbon; In tetrahydrofuran; ethanol; water; N,N-dimethyl-formamide;