2-(4-methoxybenzenesulfonyl)-2-methyl-3-[4-(2-morpholin-1-yl-ethoxy)phenyl]propionic acid hydroxyamide

Base Information

Chemical Name:2-(4-methoxybenzenesulfonyl)-2-methyl-3-[4-(2-morpholin-1-yl-ethoxy)phenyl]propionic acid hydroxyamide
CAS No.:212766-78-4
Molecular Formula:C₂₃H₃₀N₂O₇S
Molecular Weight:478.566
Hs Code.:

Synonyms:2-(4-methoxybenzenesulfonyl)-2-methyl-3-[4-(2-morpholin-1-yl-ethoxy)phenyl]propionic acid hydroxyamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-(4-methoxybenzenesulfonyl)-2-methyl-3-[4-(2-morpholin-1-yl-ethoxy)phenyl]propionic acid hydroxyamide

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Technology Process of 2-(4-methoxybenzenesulfonyl)-2-methyl-3-[4-(2-morpholin-1-yl-ethoxy)phenyl]propionic acid hydroxyamide

There total 6 articles about 2-(4-methoxybenzenesulfonyl)-2-methyl-3-[4-(2-morpholin-1-yl-ethoxy)phenyl]propionic acid hydroxyamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 212770-53-1
2-(4-methoxy-benzenesulfonyl)-2-methyl-3-[4-(2-morpholin-1-yl-ethoxy)-phenyl]-propionic acid

: 212766-78-4
2-(4-methoxybenzenesulfonyl)-2-methyl-3-[4-(2-morpholin-1-yl-ethoxy)phenyl]propionic acid hydroxyamide

Guidance literature:

Reference yield:

: 2-(4-methoxy-benzenesulfonyl)-2-methyl-3-[4-(2-morpholin-4-yl-ethoxy)-phenyl]-propionyl chloride

: 212766-78-4
2-(4-methoxybenzenesulfonyl)-2-methyl-3-[4-(2-morpholin-1-yl-ethoxy)phenyl]propionic acid hydroxyamide

Guidance literature:: With hydroxylamine; triethylamine; In tetrahydrofuran; dichloromethane; water; at 20 ℃;
DOI:10.1021/jm0205548

Reference yield:

: 696-63-9
4-Methoxybenzenethiol

: 212766-78-4
2-(4-methoxybenzenesulfonyl)-2-methyl-3-[4-(2-morpholin-1-yl-ethoxy)phenyl]propionic acid hydroxyamide

Guidance literature:: Multi-step reaction with 6 steps

1: 94 percent / K₂CO₃ / acetone / 8 h / Heating

2: 95 percent / aq. Oxone / methanol; tetrahydrofuran / 4 h / 20 °C

3: 98 percent / 18-crown-6; K₂CO₃ / acetone / Heating

4: 84 percent / aq. NaOH / methanol / 20 °C

5: (COCl)2; DMF / CH₂Cl₂ / 20 °C

6: NH₂OH; Et₃N / CH₂Cl₂; tetrahydrofuran; H₂O / 20 °C

With Oxone; sodium hydroxide; oxalyl dichloride; 18-crown-6 ether; hydroxylamine; potassium carbonate; triethylamine; N,N-dimethyl-formamide; In tetrahydrofuran; methanol; dichloromethane; water; acetone;
DOI:10.1021/jm0205548