Technology Process of dabigatran etexilate fumarate
There total 13 articles about dabigatran etexilate fumarate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
In
ethanol;
at 60 ℃;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: 1,1'-carbonyldiimidazole / tetrahydrofuran / 3 h / 25 - 35 °C
1.2: 24 h / 25 - 35 °C
1.3: 3 h / 0 - 10 °C
2.1: calcium chloride; hydrogenchloride / ethanol / 13 h / -15 - 35 °C
2.2: 23.66 h / -35 - 30 °C
3.1: dichloromethane / 3 h / 15 - 25 °C
3.2: 8 h / 25 - 50 °C
4.1: acetone / 5 h / 25 - 35 °C
With
hydrogenchloride; 1,1'-carbonyldiimidazole; calcium chloride;
In
tetrahydrofuran; ethanol; dichloromethane; acetone;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: thionyl chloride; N,N-dimethyl-formamide / toluene / 2 h / 65 - 75 °C
1.2: 3 h / 20 - 30 °C
2.1: iron; hydrogenchloride / tetrahydrofuran; water / 2 h / Reflux
3.1: 1,1'-carbonyldiimidazole / tetrahydrofuran / 3 h / 25 - 35 °C
3.2: 24 h / 25 - 35 °C
3.3: 3 h / 0 - 10 °C
4.1: calcium chloride; hydrogenchloride / ethanol / 13 h / -15 - 35 °C
4.2: 23.66 h / -35 - 30 °C
5.1: dichloromethane / 3 h / 15 - 25 °C
5.2: 8 h / 25 - 50 °C
6.1: acetone / 5 h / 25 - 35 °C
With
hydrogenchloride; thionyl chloride; iron; N,N-dimethyl-formamide; 1,1'-carbonyldiimidazole; calcium chloride;
In
tetrahydrofuran; ethanol; dichloromethane; water; acetone; toluene;
