(R)-N-((1R)-1-(diphenyl(3-((tetrahydro-2H-pyran-2-yl)oxy)propyl)silyl)-3-methylbutyl)-2-methylpropane-2-sulfinamide

Base Information

• Chemical Name: (R)-N-((1R)-1-(diphenyl(3-((tetrahydro-2H-pyran-2-yl)oxy)propyl)silyl)-3-methylbutyl)-2-methylpropane-2-sulfinamide
• CAS No.: 1227297-04-2
• Molecular Formula: C₂₉H₄₅NO₃SSi
• Molecular Weight: 515.833

Synonyms:(R)-N-((1R)-1-(diphenyl(3-((tetrahydro-2H-pyran-2-yl)oxy)propyl)silyl)-3-methylbutyl)-2-methylpropane-2-sulfinamide

Chemical Property of (R)-N-((1R)-1-(diphenyl(3-((tetrahydro-2H-pyran-2-yl)oxy)propyl)silyl)-3-methylbutyl)-2-methylpropane-2-sulfinamide

Chemical Property:

Purity/Quality:

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Technology Process of (R)-N-((1R)-1-(diphenyl(3-((tetrahydro-2H-pyran-2-yl)oxy)propyl)silyl)-3-methylbutyl)-2-methylpropane-2-sulfinamide

There total 2 articles about (R)-N-((1R)-1-(diphenyl(3-((tetrahydro-2H-pyran-2-yl)oxy)propyl)silyl)-3-methylbutyl)-2-methylpropane-2-sulfinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

(diphenyl)(3-((tetrahydro-2H-pyran-2-yl)oxy)propyl)silane (1062504-87-3) + (R,E)-2-methyl-N-(3-methylbutylidene)-2-propanesulfinamide (220315-20-8) → (R)-N-((1R)-1-(diphenyl(3-((tetrahydro-2H-pyran-2-yl)oxy)propyl)silyl)-3-methylbutyl)-2-methylpropane-2-sulfinamide (1227297-04-2)

Guidance literature:

(diphenyl)(3-((tetrahydro-2H-pyran-2-yl)oxy)propyl)silane; With lithium; In tetrahydrofuran; for 4h; Inert atmosphere;

(R,E)-2-methyl-N-(3-methylbutylidene)-2-propanesulfinamide; In tetrahydrofuran; at -78 ℃; Inert atmosphere;

With water; In tetrahydrofuran; Inert atmosphere;

DOI:10.1021/jo100301n

Reference yield:

2-(prop-2-en-1-yloxy)oxane (69161-61-1,4203-49-0) + diphenylsilane (775-12-2) → (R)-N-((1R)-1-(diphenyl(3-((tetrahydro-2H-pyran-2-yl)oxy)propyl)silyl)-3-methylbutyl)-2-methylpropane-2-sulfinamide (1227297-04-2)

Guidance literature:

Multi-step reaction with 2 steps

1.1: Wilkinson's catalyst / tetrahydrofuran / Inert atmosphere

2.1: lithium / tetrahydrofuran / Inert atmosphere

2.2: Inert atmosphere

With Wilkinson's catalyst; lithium; In tetrahydrofuran;

DOI:10.1021/jm301000k

Reference yield:

(R)-N-((1R)-1-(diphenyl(3-((tetrahydro-2H-pyran-2-yl)oxy)propyl)silyl)-3-methylbutyl)-2-methylpropane-2-sulfinamide (1227297-04-2) → C20H29NOSi*ClH

Guidance literature:

With hydrogenchloride; methanol; at 20 ℃; for 18h; Inert atmosphere;

DOI:10.1021/jo100301n

upstream raw materials:

(diphenyl)(3-((tetrahydro-2H-pyran-2-yl)oxy)propyl)silane

(R,E)-2-methyl-N-(3-methylbutylidene)-2-propanesulfinamide

2-(prop-2-en-1-yloxy)oxane

diphenylsilane

Downstream raw materials:

tert-butyl (R)-(1-((3-hydroxypropyl)diphenylsilyl)-3-methylbutyl)carbamate

C₂₅H₃₅NO₄Si

tert-butyl (R)-(1-((3-(butylamino)-3-oxopropyl)-diphenylsilyl)-3-methylbutyl)carbamate

tert-butyl ((2S,3S)-1-(((R)-1-((3-(butylamino)-3-oxopropyl)diphenylsilyl)-3-methylbutyl)-amino)-3-methyl-1-oxopentan-2-yl)carbamate

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