methyl 3(S)-<<<1-(benzyloxycarbonyl)-2(S)-pyrrolidinyl>carbonyl>amino>-2-oxo-1-perhydroazepineacetate

Base Information

Chemical Name:methyl 3(S)-<<<1-(benzyloxycarbonyl)-2(S)-pyrrolidinyl>carbonyl>amino>-2-oxo-1-perhydroazepineacetate
CAS No.:146349-41-9
Molecular Formula:C₂₂H₂₉N₃O₆
Molecular Weight:431.489
Hs Code.:

Synonyms:methyl 3(S)-<<<1-(benzyloxycarbonyl)-2(S)-pyrrolidinyl>carbonyl>amino>-2-oxo-1-perhydroazepineacetate

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Chemical Property of methyl 3(S)-<<<1-(benzyloxycarbonyl)-2(S)-pyrrolidinyl>carbonyl>amino>-2-oxo-1-perhydroazepineacetate

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Technology Process of methyl 3(S)-<<<1-(benzyloxycarbonyl)-2(S)-pyrrolidinyl>carbonyl>amino>-2-oxo-1-perhydroazepineacetate

There total 4 articles about methyl 3(S)-<<<1-(benzyloxycarbonyl)-2(S)-pyrrolidinyl>carbonyl>amino>-2-oxo-1-perhydroazepineacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 21568-87-6
2-aminocaprolactam

: 146349-41-9
methyl 3(S)-<<<1-(benzyloxycarbonyl)-2(S)-pyrrolidinyl>carbonyl>amino>-2-oxo-1-perhydroazepineacetate

Guidance literature:: Multi-step reaction with 4 steps

1: Et₃N / H₂O; dioxane / 18 h / Ambient temperature

2: 1.) NaH / 1.) THF, 30 min, 2.) THF, a) 4 deg C, 4 h, b) RT, 12 h

3: 4 N HCl / dioxane / 1.5 h

4: Et₃N / tetrahydrofuran; dimethylformamide / a) -20 deg C, 2 h, b) RT, 2 h

With hydrogenchloride; sodium hydride; triethylamine; In tetrahydrofuran; 1,4-dioxane; water; N,N-dimethyl-formamide;
DOI:10.1021/jm00054a010

Reference yield:

: 76944-95-1
tert-butyl N-[(3S)-2-oxoazepan-3-yl]carbamate

: 146349-41-9
methyl 3(S)-<<<1-(benzyloxycarbonyl)-2(S)-pyrrolidinyl>carbonyl>amino>-2-oxo-1-perhydroazepineacetate

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) NaH / 1.) THF, 30 min, 2.) THF, a) 4 deg C, 4 h, b) RT, 12 h

2: 4 N HCl / dioxane / 1.5 h

3: Et₃N / tetrahydrofuran; dimethylformamide / a) -20 deg C, 2 h, b) RT, 2 h

With hydrogenchloride; sodium hydride; triethylamine; In tetrahydrofuran; 1,4-dioxane; N,N-dimethyl-formamide;
DOI:10.1021/jm00054a010

Reference yield:

: 82611-52-7
{(3S)-3-[[(1,1-dimethylethoxy)carbonyl]amino]hexahydro-2-oxo-1H-azepine-1-yl}acetic acid methyl ester

: 146349-41-9
methyl 3(S)-<<<1-(benzyloxycarbonyl)-2(S)-pyrrolidinyl>carbonyl>amino>-2-oxo-1-perhydroazepineacetate

Guidance literature:: Multi-step reaction with 2 steps

1: 4 N HCl / dioxane / 1.5 h

2: Et₃N / tetrahydrofuran; dimethylformamide / a) -20 deg C, 2 h, b) RT, 2 h

With hydrogenchloride; triethylamine; In tetrahydrofuran; 1,4-dioxane; N,N-dimethyl-formamide;
DOI:10.1021/jm00054a010