76944-95-1

Basic information

• Product Name: (S)-(2-OXO-AZEPAN-3-YL)-CARBAMIC ACID TERT-BUTYL ESTER
• Synonyms: L-(-)-3-N-BOC-AMINO-2-AZEPANONE;L(-)-N-ALPHA-BOC-AMINO-EPSILON-CAPROLACTAM;(S)-N-BOC-ALPHA-AMINO-EPSILON-CAPROLACTAME;(S)-(2-OXO-AZEPAN-3-YL)-CARBAMIC ACID TERT-BUTYL ESTER;L-(-)-N--Boc-Amino-epsilon-caprolactam;L-(-)-N-A-BOC-AMINO-EPSILON-CAPROLACTAM;L(-)-N--Boc-Amino--caprolactam;L(-)-N-A-BOC-AMINO-E-CAPROLACTAM
• CAS NO: 76944-95-1
• Molecular Formula: C₁₁H₂₀N₂O₃
• Molecular Weight: 228.29
• Mol File: 76944-95-1.mol
• Article Data: 24

Chemical Properties

• Boiling Point: 417.7 °C at 760 mmHg
• Flash Point: 206.4 °C
• Appearance: /
• Density: 1.09
• Vapor Pressure: 3.47E-07mmHg at 25°C
• Refractive Index: 1.488
• Storage Temp.: 2-8°C
• PKA: 11.05±0.20(Predicted)
• CAS DataBase Reference: (S)-(2-OXO-AZEPAN-3-YL)-CARBAMIC ACID TERT-BUTYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-(2-OXO-AZEPAN-3-YL)-CARBAMIC ACID TERT-BUTYL ESTER(76944-95-1)
• EPA Substance Registry System: (S)-(2-OXO-AZEPAN-3-YL)-CARBAMIC ACID TERT-BUTYL ESTER(76944-95-1)

Safety Data

• Hazardous Substances Data: 76944-95-1(Hazardous Substances Data)

Usage

General Description

(S)-(2-Oxo-azepan-3-yl)-carbamic acid tert-butyl ester is a chemical compound that is used in various scientific and industrial applications. It is a tert-butyl ester derivative of (S)-2-oxoazepan-3-ylcarbamic acid, a carbamic acid derivative that is used as a reagent in the synthesis of pharmaceuticals and other organic compounds. The tert-butyl ester group provides stability and protection for the acid group, allowing for easier handling and manipulation in chemical reactions. (S)-(2-OXO-AZEPAN-3-YL)-CARBAMIC ACID TERT-BUTYL ESTER may be used as a building block in the synthesis of pharmaceuticals, agrochemicals, and other fine chemicals. It is important to handle this compound with care and in accordance with proper safety protocols due to its potential hazards.

InChI:InChI=1/C11H20N2O3/c1-11(2,3)16-10(15)13-8-6-4-5-7-12-9(8)14/h8H,4-7H2,1-3H3,(H,12,14)(H,13,15)/t8-/m0/s1

Upstream product

• 30189-36-7 N,N'-di-t-butyloxycarbonyl-(S)-lysine N-hydroxysuccinimide ester 
• 13734-28-6 Boc-Lys-OH 
• 1516-73-0 2-azido-1-methyl-1H-benzo[d]imidazole 
• 24424-99-5 di-tert-butyl dicarbonate 
• 26081-03-8 (S)-3-aminocaprolactam hydrochloride 
• 2483-46-7 Boc-Lys(Boc)-OH 
• 2389-45-9 Boc-Lys(Z)-OH 
• 1055423-27-2 (3S)-3-[[(1,1-dimethylethoxy)carbonyl]amino]hexahydro-2-oxo-1H-azepine-1-carboxylic acid phenylmethyl ester 
• 21568-87-6 2-aminocaprolactam 

Downstream Products

• 635754-97-1 (S)-1-(2-phenylethyl)-2-oxo-3-(tert-butoxycarbonylamino)-azepine 
• 258870-43-8 (S)-1-phenyl-2-oxo-3-(tert-butoxycarbonylamino)-azepine 
• 918437-67-9 7-benzyl-1-tert-butoxycarbonyl-1,7-diaza-spiro[4,6]undec-6-one 
• 918437-66-8 tert-butyl (S)-1-benzyl-2-oxazepan-3-yl-3-bromopropylcarbamate 
• 918437-79-3 (1-benzyl-2-oxo-azepan-3-yl)-(3-hydroxy-propyl)-carbamic acid tert-butyl ester 
• 209983-91-5 (S)-1-benzyl-2-oxo-3-amino-azepine 
• 643043-61-2 [(3S)-1-[((4-fluorophenyl))methyl]hexahydro-2-oxo-1H-azepin-3-yl]-carbamic acid 1,1-dimethylethyl ester 

Relevant articles and documents

(S)-2-AMINO-6-((3-AMINOPROPYL)AMINO)HEXANOIC ACID (APL) FOR USE IN THE TREATMENT OF NON-ALCOHOLIC STEATOHEPATITIS (NASH), LIVER INFLAMMATION, HEPATOCELLULAR BALLOONING, LIVER FIBROSIS AND STEATOSIS

(S)-2-amino-6-((3-aminopropyl)amino)hexanoic acid (APL) for use in the treatment of non-alcoholic steatohepatitis (NASH), liver inflammation, hepatocellular ballooning, liver fibrosis and steatosis.

COMPOSITIONS AND METHODS FOR TREATMENT OF INSULIN RESISTANCE

In certain embodiments, this disclosure relates to methods of treating or preventing type 2 diabetes, pre-diabetes and conditions characterized by an increase in the levels of AIC, glucose, insulin, homeostasis model of assessment of insulin resistance (HOMA-IR), oxidative stress in adipose tissue, and earbonvlation of GLUT4 comprising administering an effective amount of a compound of Formula I-III as described herein, to a subject in need thereof.

RIBOSOME-MEDIATED INCORPORATION OF PEPTIDES AND PEPTIDOMIMETICS

Modified ribosomes that were selected using a dipeptidyl-puromycin aminonucleoside are used to mediate site-specific incorporation of one or more peptides and peptidomimetics into protein in a cell free translation system. In addition, new fluorescent dipeptidomimetics have been synthesized and incorporated into proteins, as well as modified proteins containing one or more non-naturally occurring dipeptides.