Benclonidine

Base Information

• Chemical Name: Benclonidine
• CAS No.: 57647-79-7
• Molecular Formula: C16H13 Cl2 N3 O
• Molecular Weight: 334.205
• Mol file: 57647-79-7.mol

Synonyms:1H-Imidazol-2-amine,1-benzoyl-N-(2,6-dichlorophenyl)-4,5-dihydro- (9CI); Benchlonidine;Benclonidine

Chemical Property of Benclonidine

Chemical Property:

• Vapor Pressure: 2.68E-08mmHg at 25°C
• Boiling Point: 450.2°Cat760mmHg
• PKA: 1.55±0.70(Predicted)
• Flash Point: 226.1°C
• PSA: 44.70000
• Density: 1.38g/cm³
• LogP: 3.36380

Purity/Quality:

99% ^*data from raw suppliers

BENCLONIDINE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Benclonidine

There total 2 articles about Benclonidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-benzoyl-2-imidazolidinone (27034-77-1) + 2,6-Dichloroaniline (608-31-1) → 1-benzoyl-2-(2,6-dichloro-anilino)-4,5-dihydro-1H-imidazole (57647-79-7)

Guidance literature:

With sodium hydroxide; In (2S)-N-methyl-1-phenylpropan-2-amine hydrate; phosphorus oxychloride (POCl₃);

Reference yield:

→ 1-benzoyl-2-(2,6-dichloro-anilino)-4,5-dihydro-1H-imidazole (57647-79-7)

Guidance literature:

Benzoesaeure + N,N'-Carbonyldiimidazol + 2-(2',6'-Dichlorphenylamino)-2-imidazo- lin.;

Reference yield:

1-benzoyl-2-(2,6-dichloro-anilino)-4,5-dihydro-1H-imidazole (57647-79-7) → Clonidine (4205-90-7)

Guidance literature:

With hydrogenchloride; In methanol; ethanol;

upstream raw materials:

1-benzoyl-2-imidazolidinone

2,6-Dichloroaniline

Downstream raw materials:

Clonidine

Refernces

• 1、 -. "Imidazoline derivatives and the preparation thereof". . . Retrieved 2008/06/13.