Clonidine

Base Information Edit

Chemical Name:Clonidine
CAS No.:4205-90-7
Deprecated CAS:57066-25-8
Molecular Formula:C9H9 Cl2 N3
Molecular Weight:230.097
Hs Code.:2933290000
European Community (EC) Number:224-119-4
UNII:MN3L5RMN02
DSSTox Substance ID:DTXSID6022846
Nikkaji Number:J9.618K
Wikipedia:Clonidine
Wikidata:Q412221
NCI Thesaurus Code:C380
RXCUI:2599
Pharos Ligand ID:S5T1CH4J9YSY
Metabolomics Workbench ID:42907
ChEMBL ID:CHEMBL134
Mol file:4205-90-7.mol

Synonyms:Catapres;Catapresan;Catapressan;Chlophazolin;Clofelin;Clofenil;Clonidine;Clonidine Dihydrochloride;Clonidine Hydrochloride;Clonidine Monohydrobromide;Clonidine Monohydrochloride;Clopheline;Dihydrochloride, Clonidine;Dixarit;Gemiton;Hemiton;Hydrochloride, Clonidine;Isoglaucon;Klofelin;Klofenil;M 5041T;M-5041T;M5041T;Monohydrobromide, Clonidine;Monohydrochloride, Clonidine;ST 155;ST-155;ST155

Suppliers and Price of Clonidine

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
Clonidine
1g
$ 220.00

TRC
Clonidine
100mg
$ 90.00

Sigma-Aldrich
Clonidine solution 1.0?mg/mL in methanol, ampule of 1?mL, certified reference material, Cerilliant?
1 mL
$ 52.40

Sigma-Aldrich
Clonidine solution 1.0mg/mL in methanol, ampule of 1mL, certified reference material
033-1ml
$ 50.80

Sigma-Aldrich
Clonidine solution
200mg
$ 366.00

ChemScene
Clonidine 98.79%
100mg
$ 105.00

ChemScene
Clonidine 98.79%
1g
$ 360.00

ChemScene
Clonidine 98.79%
250mg
$ 175.00

AvaChem
Clonidine
5g
$ 150.00

AvaChem
Clonidine
1g
$ 49.00

Total 63 raw suppliers

Chemical Property of Clonidine Edit

Chemical Property:

Melting Point:141-142℃
Refractive Index:1.6300 (estimate)
Boiling Point:319.3°Cat760mmHg
PKA:8.10±0.50(Predicted)
Flash Point:146.9°C
PSA：36.42000
Density:1.5g/cm³
LogP:2.20190
Storage Temp.:?20°C
XLogP3:1.6
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:1
Rotatable Bond Count:2
Exact Mass:229.0173527
Heavy Atom Count:14
Complexity:222

Purity/Quality:

99% ^*data from raw suppliers

Clonidine ^*data from reagent suppliers

Safty Information:

Pictogram(s): F,T
Hazard Codes:F,T
Statements: 11-23/24/25-39/23/24/25
Safety Statements: 16-36/37-45

MSDS Files:: SDS file from LookChem

Useful:

Drug Classes:Antihypertensive Agents
Canonical SMILES:C1CN=C(N1)NC2=C(C=CC=C2Cl)Cl
Recent ClinicalTrials:Solifenacin Compared to Clonidine for Reducing Hot Flashes Among Breast Cancer Patients
Recent EU Clinical Trials:Intraoperative clonidine for postoperative pain management in patients undergoing surgical treatment for endometriosis: a prospective, double-blind, randomized controlled trial
Recent NIPH Clinical Trials:Comparision of Anesthetic drug combinations Bupivacaine with clonidine and Levobupivacaine with clonidine used in nerve blocks for surgeries of upper limb
Uses Antihypertensive. Clonidine may be useful in the treatment of acute opioid withdrawal. Epidural clonidine 1–2μgkg –1 increases the duration and potency of analgesia provided by epidural opioid or local anaesthetic drugs.

Technology Process of Clonidine

There total 21 articles about Clonidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%