5-bromo-N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-2-methyl-3-(methyl(piperidin-4-yl)amino)benzamide

Base Information

Chemical Name:5-bromo-N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-2-methyl-3-(methyl(piperidin-4-yl)amino)benzamide
CAS No.:1403590-51-1
Molecular Formula:C₂₂H₂₉BrN₄O₂
Molecular Weight:461.402
Hs Code.:

Synonyms:5-bromo-N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-2-methyl-3-(methyl(piperidin-4-yl)amino)benzamide

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Chemical Property of 5-bromo-N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-2-methyl-3-(methyl(piperidin-4-yl)amino)benzamide

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Technology Process of 5-bromo-N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-2-methyl-3-(methyl(piperidin-4-yl)amino)benzamide

There total 11 articles about 5-bromo-N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-2-methyl-3-(methyl(piperidin-4-yl)amino)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 1403257-59-9
tert-butyl 4-((5-bromo-3-(((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)carbamoyl)-2-methylphenyl)(methyl)amino)piperidin-1-carboxylate

: 1403590-51-1
5-bromo-N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-2-methyl-3-(methyl(piperidin-4-yl)amino)benzamide

Guidance literature:: tert-butyl 4-((5-bromo-3-(((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)carbamoyl)-2-methylphenyl)(methyl)amino)piperidin-1-carboxylate; With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 1h;

With sodium hydrogencarbonate; In water; pH=8;

Reference yield:

: 1000342-11-9
2-methyl-3-amino-5-bromobenzoic acid methyl ester

: 1403590-51-1
5-bromo-N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-2-methyl-3-(methyl(piperidin-4-yl)amino)benzamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: acetic acid / methanol / 3 h / 20 °C

1.2: 0 - 20 °C

2.1: caesium carbonate / acetonitrile / 7 h / 80 °C

3.1: sodium hydroxide; water / methanol / 1 h / 60 °C

3.2: pH 4 - 6

4.1: dimethyl sulfoxide / 0.25 h / 20 °C

5.1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

5.2: pH 8

With water; caesium carbonate; acetic acid; trifluoroacetic acid; sodium hydroxide; In methanol; dichloromethane; dimethyl sulfoxide; acetonitrile;

Reference yield:

: 1403257-57-7
tert-butyl 4-((5-bromo-3-(methoxycarbonyl)-2-methylphenyl)amino)piperidine-1-carboxylate

: 1403590-51-1
5-bromo-N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-2-methyl-3-(methyl(piperidin-4-yl)amino)benzamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: caesium carbonate / acetonitrile / 7 h / 80 °C

2.1: sodium hydroxide; water / methanol / 1 h / 60 °C

2.2: pH 4 - 6

3.1: dimethyl sulfoxide / 0.25 h / 20 °C

4.1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

4.2: pH 8

With water; caesium carbonate; trifluoroacetic acid; sodium hydroxide; In methanol; dichloromethane; dimethyl sulfoxide; acetonitrile;