tert-butyl 4-((5-bromo-3-(((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)carbamoyl)-2-methylphenyl)(methyl)amino)piperidin-1-carboxylate

Base Information

Chemical Name:tert-butyl 4-((5-bromo-3-(((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)carbamoyl)-2-methylphenyl)(methyl)amino)piperidin-1-carboxylate
CAS No.:1403257-59-9
Molecular Formula:C₂₇H₃₇BrN₄O₄
Molecular Weight:561.519
Hs Code.:

Synonyms:tert-butyl 4-((5-bromo-3-(((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)carbamoyl)-2-methylphenyl)(methyl)amino)piperidin-1-carboxylate

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Chemical Property of tert-butyl 4-((5-bromo-3-(((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)carbamoyl)-2-methylphenyl)(methyl)amino)piperidin-1-carboxylate

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Technology Process of tert-butyl 4-((5-bromo-3-(((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)carbamoyl)-2-methylphenyl)(methyl)amino)piperidin-1-carboxylate

There total 10 articles about tert-butyl 4-((5-bromo-3-(((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)carbamoyl)-2-methylphenyl)(methyl)amino)piperidin-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: 771579-27-2
3-(aminomethyl)-4,6-dimethyl-1,2-dihydropyridin-2-one

: 1403257-60-2
C₁₉H₂₇BrN₂O₄

: 1403257-59-9
tert-butyl 4-((5-bromo-3-(((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)carbamoyl)-2-methylphenyl)(methyl)amino)piperidin-1-carboxylate

Guidance literature:: 3-(aminomethyl)-4,6-dimethyl-1,2-dihydropyridin-2-one; C₁₉H₂₇BrN₂O₄; In dimethyl sulfoxide; at 20 ℃; for 0.25h;

With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; In dimethyl sulfoxide;

Reference yield:

: 1000342-11-9
2-methyl-3-amino-5-bromobenzoic acid methyl ester

: 1403257-59-9
tert-butyl 4-((5-bromo-3-(((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)carbamoyl)-2-methylphenyl)(methyl)amino)piperidin-1-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: acetic acid / methanol / 3 h / 20 °C

1.2: 0 - 20 °C

2.1: caesium carbonate / acetonitrile / 7 h / 80 °C

3.1: sodium hydroxide; water / methanol / 1 h / 60 °C

3.2: pH 4 - 6

4.1: dimethyl sulfoxide / 0.25 h / 20 °C

With water; caesium carbonate; acetic acid; sodium hydroxide; In methanol; dimethyl sulfoxide; acetonitrile;

Reference yield:

: 771579-27-2
3-(aminomethyl)-4,6-dimethylpyridin-2-ol

: 1403257-60-2
C₁₉H₂₇BrN₂O₄

: 1403257-59-9
tert-butyl 4-((5-bromo-3-(((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)carbamoyl)-2-methylphenyl)(methyl)amino)piperidin-1-carboxylate

Guidance literature:: With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; In dimethyl sulfoxide; at 20 ℃;
DOI:10.1021/acs.jmedchem.5b01501