L-SERINE-1-13C

Base Information

• Chemical Name: L-SERINE-1-13C
• CAS No.: 81201-84-5
• Molecular Formula: C3H7NO3
• Molecular Weight: 106.1
• Mol file: 81201-84-5.mol

Synonyms:DL-<1-(13)C>serine;N,N'-bis-glycyl-L-cystine;N,N'-Digylcyl-L-cystin;(R,S)-serine-1-(13)C;N,N'-Diglycyl-L-cystin;N,N'-Diglycyl-L-cystein;N,N'-bis-L-glycyl-L-cystine;(R:R)-Bis-[2-(aminoacetyl-amino)-2-carboxy-aethyl]-disulfid;2-[(2-aminoacetyl)amino]-3-[[2-[(2-aminoacetyl)amino]-3-hydroxy-3-oxopropyl]disulfanyl]propanoic acid;

Chemical Property of L-SERINE-1-13C

Chemical Property:

• Melting Point: 222oC (dec.)(lit.)
• PSA: 83.55000
• Density: 1.415g/cm³
• LogP: -0.90910
• Storage Temp.: 4°C
• Solubility.: Methanol (Slightly), Water (Slightly)

Purity/Quality:

98%,99%, ^*data from raw suppliers

L-Serine-13C ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: L-Serine-13C can be used for in vivo assays of transaminase activity

Technology Process of L-SERINE-1-13C

There total 2 articles about L-SERINE-1-13C which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

glycine-1-(13)C → DL-<1-(13)C>serine (81201-84-5,84344-20-7)

Guidance literature:

DOI:10.1016/0040-4020(82)85150-8

Reference yield:

(R)-serine-(13)C (1202064-08-1) → DL-<1-(13)C>serine (81201-84-5,84344-20-7)

Guidance literature:

DOI:10.1016/0040-4020(82)85150-8

Reference yield:

DL-<1-(13)C>serine (81201-84-5,84344-20-7) + trifluoroacetic acid (76-05-1) → C2HF3O2*C39(13)CH44N2O19 (1372782-45-0)

Guidance literature:

DL-<1-(13)C>serine; Actinomodura sp. TP-A₀₀₁₉; In acetonitrile; for 194h;

trifluoroacetic acid; In water; acetone;

DOI:10.1016/j.bmcl.2011.11.106

upstream raw materials:

(R)-serine-⁽¹³⁾C

Downstream raw materials:

C₂HF₃O₂*C₃₉⁽¹³⁾CH₄₄N₂O₁₉

Refernces

SYNTHESIS OF (13)C AND (15)N LABELED (S)-TRYPTOPHAN

10.1016/0040-4020(82)85150-8

The research aimed to synthesize 13C and 15N labeled (S)-tryptophan, a crucial amino acid used in biosynthetic studies of various compounds and for conformational studies in proteins. The study utilized a biosynthetic approach involving the incubation of (R,S)-serine-1-13C in a culture of Escherichia coli cells, which were engineered to produce (S)-tryptophan-1-13C. Additionally, the researchers synthesized indole-3-13C and indole-15N through known chemical sequences, and these isotopes were then converted by the E. coli to yield (S)-tryptophan-1-13C and (S)-tryptophan-indole-15N, respectively. The chemicals used in this process included (R,S)-serine-1-13C, bromoacetyl bromide-2-13C and 15N-labeled aniline, among others. The conclusions of the study highlighted the efficiency of this biosynthetic method, which could accommodate various labeling patterns and was considered the simplest route for the preparation of optically active products, with yields ranging from 40 to 50%.

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