1,1,1-trifluoro-2-methylpropan-2-yl 4-[4-({6-fluoro-2-[(4-methoxybenzyl)amino]-1-benzothiophen-3-yl}carbonyl)-piperazin-1-yl]piperidine-1-carboxylate

Base Information

Chemical Name:1,1,1-trifluoro-2-methylpropan-2-yl 4-[4-({6-fluoro-2-[(4-methoxybenzyl)amino]-1-benzothiophen-3-yl}carbonyl)-piperazin-1-yl]piperidine-1-carboxylate
CAS No.:1209008-33-2
Molecular Formula:C₃₁H₃₆F₄N₄O₄S
Molecular Weight:636.711
Hs Code.:

1,1,1-trifluoro-2-methylpropan-2-yl 4-[4-({6-fluoro-2-[(4-methoxybenzyl)amino]-1-benzothiophen-3-yl}carbonyl)-piperazin-1-yl]piperidine-1-carboxylate

Synonyms:1,1,1-trifluoro-2-methylpropan-2-yl 4-[4-({6-fluoro-2-[(4-methoxybenzyl)amino]-1-benzothiophen-3-yl}carbonyl)-piperazin-1-yl]piperidine-1-carboxylate

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Chemical Property of 1,1,1-trifluoro-2-methylpropan-2-yl 4-[4-({6-fluoro-2-[(4-methoxybenzyl)amino]-1-benzothiophen-3-yl}carbonyl)-piperazin-1-yl]piperidine-1-carboxylate

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Technology Process of 1,1,1-trifluoro-2-methylpropan-2-yl 4-[4-({6-fluoro-2-[(4-methoxybenzyl)amino]-1-benzothiophen-3-yl}carbonyl)-piperazin-1-yl]piperidine-1-carboxylate

There total 10 articles about 1,1,1-trifluoro-2-methylpropan-2-yl 4-[4-({6-fluoro-2-[(4-methoxybenzyl)amino]-1-benzothiophen-3-yl}carbonyl)-piperazin-1-yl]piperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 1209007-74-8
6-fluoro-2-[(4-methoxybenzyl)amino]-1-benzothiophene-3-carboxylic acid

: 1209008-04-7
1,1,1-trifluoro-2-methylpropan-2-yl 4-(piperazin-1-yl)piperidine-1-carboxylate

: 1209008-33-2
1,1,1-trifluoro-2-methylpropan-2-yl 4-[4-({6-fluoro-2-[(4-methoxybenzyl)amino]-1-benzothiophen-3-yl}carbonyl)-piperazin-1-yl]piperidine-1-carboxylate

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In N,N-dimethyl-formamide; for 20h;
DOI:10.1016/j.bmc.2011.01.041

Reference yield:

: 1209007-71-5
tert-butyl ethyl (4-fluoro-2-nitrophenyl)propanedioate

: 1209008-33-2
1,1,1-trifluoro-2-methylpropan-2-yl 4-[4-({6-fluoro-2-[(4-methoxybenzyl)amino]-1-benzothiophen-3-yl}carbonyl)-piperazin-1-yl]piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: toluene-4-sulfonic acid / toluene / 4 h / Reflux

2: sodium hydride / dimethyl sulfoxide; mineral oil / 2 h / 20 - 120 °C

3: sodium hydroxide / tetrahydrofuran; ethanol; water / 3 h / Reflux

4: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / N,N-dimethyl-formamide / 20 h

With sodium hydride; benzotriazol-1-ol; toluene-4-sulfonic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; sodium hydroxide; In tetrahydrofuran; ethanol; water; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene; mineral oil;
DOI:10.1016/j.bmc.2011.01.041

Reference yield:

: 1209008-02-5
1,1,1-trifluoro-2-methylpropan-2-yl 4-oxopiperidine-1-carboxylate

: 1209008-33-2
1,1,1-trifluoro-2-methylpropan-2-yl 4-[4-({6-fluoro-2-[(4-methoxybenzyl)amino]-1-benzothiophen-3-yl}carbonyl)-piperazin-1-yl]piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: chloroform / 1.5 h / 20 °C

1.2: 5 h

2.1: hydrogenchloride / ethyl acetate / 5 h

3.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / N,N-dimethyl-formamide / 20 h

With hydrogenchloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In chloroform; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2011.01.041