tert-butyl ethyl (4-fluoro-2-nitrophenyl)propanedioate

Base Information

Chemical Name:tert-butyl ethyl (4-fluoro-2-nitrophenyl)propanedioate
CAS No.:1209007-71-5
Molecular Formula:C₁₅H₁₈FNO₆
Molecular Weight:327.309
Hs Code.:

Synonyms:tert-butyl ethyl (4-fluoro-2-nitrophenyl)propanedioate

Suppliers and Price of tert-butyl ethyl (4-fluoro-2-nitrophenyl)propanedioate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of tert-butyl ethyl (4-fluoro-2-nitrophenyl)propanedioate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of tert-butyl ethyl (4-fluoro-2-nitrophenyl)propanedioate

There total 1 articles about tert-butyl ethyl (4-fluoro-2-nitrophenyl)propanedioate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 32864-38-3
tert-Butyl ethyl malonate

: 364-74-9
1,4-difluoro-2-nitrobenzene

: 1209007-71-5
tert-butyl ethyl (4-fluoro-2-nitrophenyl)propanedioate

Guidance literature:: tert-Butyl ethyl malonate; With sodium hydride; In tetrahydrofuran; mineral oil; at 20 ℃; for 0.25h;

1,4-difluoro-2-nitrobenzene; In tetrahydrofuran; mineral oil; at 60 ℃; for 5h;
DOI:10.1016/j.bmc.2011.01.041

Reference yield: 75.0%

: 1209007-71-5
tert-butyl ethyl (4-fluoro-2-nitrophenyl)propanedioate

: 1209007-72-6
ethyl 2-(4-fluoro-2-nitrophenyl)acetate

Guidance literature:: With toluene-4-sulfonic acid; In toluene; for 4h; Reflux;
DOI:10.1016/j.bmc.2011.01.041

Reference yield:

: 1209007-71-5
tert-butyl ethyl (4-fluoro-2-nitrophenyl)propanedioate

: 1209008-33-2
1,1,1-trifluoro-2-methylpropan-2-yl 4-[4-({6-fluoro-2-[(4-methoxybenzyl)amino]-1-benzothiophen-3-yl}carbonyl)-piperazin-1-yl]piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: toluene-4-sulfonic acid / toluene / 4 h / Reflux

2: sodium hydride / dimethyl sulfoxide; mineral oil / 2 h / 20 - 120 °C

3: sodium hydroxide / tetrahydrofuran; ethanol; water / 3 h / Reflux

4: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / N,N-dimethyl-formamide / 20 h

With sodium hydride; benzotriazol-1-ol; toluene-4-sulfonic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; sodium hydroxide; In tetrahydrofuran; ethanol; water; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene; mineral oil;
DOI:10.1016/j.bmc.2011.01.041