1,1-Dimethylethyl 4-(aminocarbonyl)-4-[(2-phenylethyl)amino]-1-piperidinecarboxylate

Base Information

Chemical Name:1,1-Dimethylethyl 4-(aminocarbonyl)-4-[(2-phenylethyl)amino]-1-piperidinecarboxylate
CAS No.:288154-19-8
Molecular Formula:C₁₉H₂₉N₃O₃
Molecular Weight:347.458
Hs Code.:
DSSTox Substance ID:DTXSID501128545

Synonyms:DTXSID501128545;1,1-Dimethylethyl 4-(aminocarbonyl)-4-[(2-phenylethyl)amino]-1-piperidinecarboxylate;288154-19-8

Suppliers and Price of 1,1-Dimethylethyl 4-(aminocarbonyl)-4-[(2-phenylethyl)amino]-1-piperidinecarboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 1,1-Dimethylethyl 4-(aminocarbonyl)-4-[(2-phenylethyl)amino]-1-piperidinecarboxylate

Chemical Property:

XLogP3:1.9
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:7
Exact Mass:347.22089180
Heavy Atom Count:25
Complexity:459

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC(C)(C)OC(=O)N1CCC(CC1)(C(=O)N)NCCC2=CC=CC=C2

Technology Process of 1,1-Dimethylethyl 4-(aminocarbonyl)-4-[(2-phenylethyl)amino]-1-piperidinecarboxylate

There total 4 articles about 1,1-Dimethylethyl 4-(aminocarbonyl)-4-[(2-phenylethyl)amino]-1-piperidinecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 122-78-1
phenylacetaldehyde

: 288154-18-7
tert-butyl 4-amino-4-carbamoylpiperidine-1-carboxylate

: 288154-19-8
1-Boc-4-[(2-phenylethyl)amino]piperidine-4-carboxamide

Guidance literature:: With sodium cyanoborohydride; acetic acid; In methanol; at 20 ℃; for 1h;
DOI:10.1021/jm990962k

Reference yield:

: 288154-16-5
4-(Benzyloxycarbonylamino)-1-(tert-butoxycarbonyl)-piperidine-4-carboxylic Acid

: 288154-19-8
1-Boc-4-[(2-phenylethyl)amino]piperidine-4-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1: NMM / 1,2-dimethoxy-ethane / 0.08 h / -15 °C

2: aq. NH₃ / 1,2-dimethoxy-ethane / 1 h / 20 °C

3: 100 percent / aq. HCl / 10percent Pd/C / ethanol / 20 °C

4: 62 percent / NaBH₃CN; AcOH / methanol / 1 h / 20 °C

With 4-methyl-morpholine; hydrogenchloride; ammonium hydroxide; sodium cyanoborohydride; acetic acid; 10percent Pd/C; In methanol; 1,2-dimethoxyethane; ethanol; 1: Acylation / 2: ammonolysis / 3: Hydrogenolysis / 4: reductive amination;
DOI:10.1021/jm990962k

Reference yield:

: 288154-17-6
1-Boc-4-[Z-amino]piperidine-4-carboxamide

: 288154-19-8
1-Boc-4-[(2-phenylethyl)amino]piperidine-4-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: 100 percent / aq. HCl / 10percent Pd/C / ethanol / 20 °C

2: 62 percent / NaBH₃CN; AcOH / methanol / 1 h / 20 °C

With hydrogenchloride; sodium cyanoborohydride; acetic acid; 10percent Pd/C; In methanol; ethanol; 1: Hydrogenolysis / 2: reductive amination;
DOI:10.1021/jm990962k