4-(((Benzyloxy)carbonyl)amino)-1-(tert-butoxycarbonyl)piperidine-4-carboxylic acid

Base Information

Chemical Name:4-(((Benzyloxy)carbonyl)amino)-1-(tert-butoxycarbonyl)piperidine-4-carboxylic acid
CAS No.:288154-16-5
Molecular Formula:C19H26 N2 O6
Molecular Weight:378.425
Hs Code.:29333990
European Community (EC) Number:672-463-2
DSSTox Substance ID:DTXSID20373460
Nikkaji Number:J2.494.380A
Wikidata:Q72441917
Mol file:288154-16-5.mol

Synonyms:288154-16-5;4-(((Benzyloxy)carbonyl)amino)-1-(tert-butoxycarbonyl)piperidine-4-carboxylic acid;4-benzyloxycarbonylamino-piperidine-1,4-dicarboxylic acid mono-tert-butyl ester;1-boc-4-n-cbz-aminoisonipecotic acid;1-Boc-4-(Cbz-amino)piperidine-4-carboxylic Acid;1-[(2-methylpropan-2-yl)oxycarbonyl]-4-(phenylmethoxycarbonylamino)piperidine-4-carboxylic acid;1-n-boc-4-(n-cbz-amino)piperidine-4-carboxylic acid;MFCD02683056;4-(benzyloxycarbonylamino)-1-(tert-butoxycarbonyl)piperidine-4-carboxylic acid;4-[(Benzyloxycarbonyl)amino]piperidine-1,4-dicarboxylic acid mono-tert-butyl ester;Z-4-AMINO-1-BOC-PIPERIDINE-4-CARBOXYLIC ACID;4-{[(benzyloxy)carbonyl]amino}-1-(tert-butoxycarbonyl)piperidine-4-carboxylic acid;z-pip(boc)-oh;1-Boc-4-N-Cbz-aminopiperidine-4-carboxylicacid;SCHEMBL2206561;DTXSID20373460;IHSWVSORYDACRV-UHFFFAOYSA-N;4-(benzyloxycarbonylamino)-1-tert-butoxycarbonyl-piperidine-4-carboxylic acid;AKOS015912691;AB12308;CS-W002961;DS-12565;SY005251;FT-0644346;EN300-316365;Cbz-4-amino-1-Boc-piperidine-4-carboxylic acid;1-n-boc-4-n-cbz-amino-piperidine-4-carboxylic acid;4-(cbz-amino)-1-(boc)piperidine-4-carboxylic acid;A1-01784;Q-103183;4-(benzyloxycarbonyl)-1-(tert-butoxycarbonyl)piperidine-4-carboxylic acid;4-benzyloxycarbonylamino-1-tert-butoxycarbonylpiperidine-4-carboxylic acid;4-Benzyloxycarbonylaminopiperidine-1,4-dicarboxylic acid monotertbutyl ester;4-(Benzyloxycarbonylamino)-1-(tert-butoxycarbonyl)-piperidine-4-carboxylic Acid;4-[(Benzyloxycarbonyl)amino]piperidine-1,4-dicarboxylic acid 1-tert-butyl ester;4-{[(benzyloxy)carbonyl]amino}-1-[(tert-butoxy)carbonyl]piperidine-4-carboxylic acid;4-Benzyloxycarbonylaminopiperidine-1,4-dicarboxylic acid mono-tert-butyl ester;1-{[(1,1-dimethylethyl)oxy]carbonyl}-4-({[(phenylmethyl)oxy]carbonyl}amino)-4-piperidinecarboxylic acid

Suppliers and Price of 4-(((Benzyloxy)carbonyl)amino)-1-(tert-butoxycarbonyl)piperidine-4-carboxylic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
Z-4-amino-1-Boc-piperidine-4-carboxylic acid
250mg
$ 393.00

TRC
1-BOC-4-N-CBZ-AminoisonipecoticAcid
250mg
$ 75.00

Labseeker
1-N-BOC-4-N-CBZ-AMINO-PIPERIDINE-4-CARBOXYLICACID 95
5g
$ 647.00

Crysdot
4-(((Benzyloxy)carbonyl)amino)-1-(tert-butoxycarbonyl)piperidine-4-carboxylicacid 97%
25g
$ 658.00

Chem-Impex
1-Boc-4-N-Z-aminoisonipecoticacid,97%(HPLC) 97%(HPLC)
1G
$ 61.60

Chem-Impex
1-Boc-4-N-Z-aminoisonipecoticacid,≥97%(HPLC) ≥97%(HPLC)
5G
$ 291.20

Chemenu
1-Boc-4-(Cbz-amino)piperidine-4-carboxylicAcid 97%
5g
$ 245.00

Biosynth Carbosynth
Z-4-amino-1-Boc-piperidine-4-carboxylic acid
1 g
$ 202.40

Biosynth Carbosynth
Z-4-amino-1-Boc-piperidine-4-carboxylic acid
500 mg
$ 125.00

Biosynth Carbosynth
Z-4-amino-1-Boc-piperidine-4-carboxylic acid
250 mg
$ 77.50

Total 28 raw suppliers

Chemical Property of 4-(((Benzyloxy)carbonyl)amino)-1-(tert-butoxycarbonyl)piperidine-4-carboxylic acid

Chemical Property:

Vapor Pressure:3.35E-13mmHg at 25°C
Boiling Point:556.1°Cat760mmHg
PKA:3.84±0.20(Predicted)
Flash Point:290.1°C
PSA：105.17000
Density:1.26g/cm³
LogP:3.09590
Storage Temp.:2-8°C
XLogP3:2.3
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:7
Exact Mass:378.17908655
Heavy Atom Count:27
Complexity:543

Purity/Quality:

97% ^*data from raw suppliers

Z-4-amino-1-Boc-piperidine-4-carboxylic acid ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:
Statements: 36/37/38
Safety Statements: 26-36/37/39

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(C)(C)OC(=O)N1CCC(CC1)(C(=O)O)NC(=O)OCC2=CC=CC=C2

Technology Process of 4-(((Benzyloxy)carbonyl)amino)-1-(tert-butoxycarbonyl)piperidine-4-carboxylic acid

There total 10 articles about 4-(((Benzyloxy)carbonyl)amino)-1-(tert-butoxycarbonyl)piperidine-4-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 501-53-1,94274-21-2
benzyl chloroformate

: 183673-71-4
4-amino-1-(tert-butoxycarbonyl)piperidine-4-carboxylic acid

: 288154-16-5
4-(Benzyloxycarbonylamino)-1-(tert-butoxycarbonyl)-piperidine-4-carboxylic Acid

Guidance literature:: With potassium carbonate; In 1,4-dioxane; water; at 20 ℃;
DOI:10.1016/j.bmcl.2007.02.023

Reference yield: 71.0%

: 501-53-1,94274-21-2
benzyl chloroformate

: 183673-68-9
1-tert-butyloxycarbonylpiperidine-4-spiro-5'-(1',3'-bis(tertbutyloxy-carbonyl))hydantoin

: 288154-16-5
4-(Benzyloxycarbonylamino)-1-(tert-butoxycarbonyl)-piperidine-4-carboxylic Acid

Guidance literature:: benzyl chloroformate; 1-tert-butyloxycarbonylpiperidine-4-spiro-5'-(1',3'-bis(tertbutyloxy-carbonyl))hydantoin; With sodium hydroxide; In tetrahydrofuran; water; at 0 - 20 ℃;

With hydrogenchloride; In water; pH=2.5;

Reference yield:

: 321997-89-1
methyl 1-tert-butyloxycarbonyl-4-aminopiperidin-4-carboxylate

: 501-53-1,94274-21-2
benzyl chloroformate

: 288154-16-5
4-(Benzyloxycarbonylamino)-1-(tert-butoxycarbonyl)-piperidine-4-carboxylic Acid

Guidance literature:: methyl 1-tert-butyloxycarbonyl-4-aminopiperidin-4-carboxylate; benzyl chloroformate; With water; sodium carbonate; In 1,4-dioxane; at 20 ℃; for 6h;

With hydrogenchloride; In water;