3-(2-{benzyloxycarbonyl-[4-(4-methanesulfonylaminophenyl)butyl]amino}ethyl)-2-(3,5-dimethylphenyl)-1H-indole-5-carboxylic acid

Base Information

Chemical Name:3-(2-{benzyloxycarbonyl-[4-(4-methanesulfonylaminophenyl)butyl]amino}ethyl)-2-(3,5-dimethylphenyl)-1H-indole-5-carboxylic acid
CAS No.:192774-19-9
Molecular Formula:C₃₈H₄₁N₃O₆S
Molecular Weight:667.826
Hs Code.:

Synonyms:3-(2-{benzyloxycarbonyl-[4-(4-methanesulfonylaminophenyl)butyl]amino}ethyl)-2-(3,5-dimethylphenyl)-1H-indole-5-carboxylic acid

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Chemical Property of 3-(2-{benzyloxycarbonyl-[4-(4-methanesulfonylaminophenyl)butyl]amino}ethyl)-2-(3,5-dimethylphenyl)-1H-indole-5-carboxylic acid

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Technology Process of 3-(2-{benzyloxycarbonyl-[4-(4-methanesulfonylaminophenyl)butyl]amino}ethyl)-2-(3,5-dimethylphenyl)-1H-indole-5-carboxylic acid

There total 11 articles about 3-(2-{benzyloxycarbonyl-[4-(4-methanesulfonylaminophenyl)butyl]amino}ethyl)-2-(3,5-dimethylphenyl)-1H-indole-5-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 192774-18-8
3-(2-{benzyloxycarbonyl-[4-(4-methanesulfonylamino-phenyl)butyl]amino}ethyl)-2-(3,5-dimethylphenyl)-1H-indole-5-carboxylic acid ethyl ester

: 192774-19-9
3-(2-{benzyloxycarbonyl-[4-(4-methanesulfonylaminophenyl)butyl]amino}ethyl)-2-(3,5-dimethylphenyl)-1H-indole-5-carboxylic acid

Guidance literature:: With potassium hydroxide; In methanol; Heating;
DOI:10.1016/S0960-894X(01)00274-8

Reference yield:

: 5600-62-4
4-(4-nitrophenyl)butanoic acid

: 192774-19-9
3-(2-{benzyloxycarbonyl-[4-(4-methanesulfonylaminophenyl)butyl]amino}ethyl)-2-(3,5-dimethylphenyl)-1H-indole-5-carboxylic acid

Guidance literature:: Multi-step reaction with 8 steps

1: BOP; Et₃N / CH₂Cl₂

2: H₂ / Pd(OH)2/C / ethanol

3: pyridine

4: LiAlH₄ / tetrahydrofuran / 0 °C

5: MgSO₄ / CDCl₃ / -10 - -5 °C

6: NaBH₄ / methanol / -5 °C

7: i-Pr₂NEt / CH₂Cl₂; tetrahydrofuran / -78 °C

8: aq. KOH / methanol / Heating

With pyridine; potassium hydroxide; sodium tetrahydroborate; lithium aluminium tetrahydride; hydrogen; magnesium sulfate; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; N-ethyl-N,N-diisopropylamine; palladium dihydroxide; In tetrahydrofuran; methanol; chloroform-d1; ethanol; dichloromethane;
DOI:10.1016/S0960-894X(01)00274-8

Reference yield:

: 192774-14-4
4-(4-nitrophenyl)butyric acid, N-methoxy-N-methylamide

: 192774-19-9
3-(2-{benzyloxycarbonyl-[4-(4-methanesulfonylaminophenyl)butyl]amino}ethyl)-2-(3,5-dimethylphenyl)-1H-indole-5-carboxylic acid

Guidance literature:: Multi-step reaction with 7 steps

1: H₂ / Pd(OH)2/C / ethanol

2: pyridine

3: LiAlH₄ / tetrahydrofuran / 0 °C

4: MgSO₄ / CDCl₃ / -10 - -5 °C

5: NaBH₄ / methanol / -5 °C

6: i-Pr₂NEt / CH₂Cl₂; tetrahydrofuran / -78 °C

7: aq. KOH / methanol / Heating

With pyridine; potassium hydroxide; sodium tetrahydroborate; lithium aluminium tetrahydride; hydrogen; magnesium sulfate; N-ethyl-N,N-diisopropylamine; palladium dihydroxide; In tetrahydrofuran; methanol; chloroform-d1; ethanol; dichloromethane;
DOI:10.1016/S0960-894X(01)00274-8