C₁₃H₁₇F

Base Information

• Chemical Name: C₁₃H₁₇F
• CAS No.: 1407518-44-8
• Molecular Formula: C₁₃H₁₇F
• Molecular Weight: 192.276
• Mol file: 1407518-44-8.mol

Synonyms:C₁₃H₁₇F

Chemical Property of C₁₃H₁₇F

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

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Technology Process of C₁₃H₁₇F

There total 6 articles about C₁₃H₁₇F which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 29.0%

n-butyl magnesium bromide (693-03-8) + diethyl (2Z)-3-fluoro-3-phenylprop-2-en-1-yl phosphate (1407518-30-2) → C13H17F (1407518-44-8)

Guidance literature:

n-butyl magnesium bromide; With copper(I) bromide; In tetrahydrofuran; at -78 - -10 ℃; for 0.333333h; Inert atmosphere;

diethyl (2Z)-3-fluoro-3-phenylprop-2-en-1-yl phosphate; at -40 ℃; for 0.5h; Temperature; Reagent/catalyst; Concentration; regioselective reaction;

DOI:10.1039/c2ob25718a

Reference yield:

n-butyl magnesium bromide (693-03-8) + diethyl (2Z)-3-fluoro-3-phenylprop-2-en-1-yl phosphate (1407518-30-2) → 3-fluoro-3-phenyl-1-heptene (1407518-47-1) + C13H17F (1407518-44-8)

Guidance literature:

n-butyl magnesium bromide; With copper(l) cyanide; In tetrahydrofuran; at -78 - -10 ℃; for 0.333333h; Inert atmosphere;

diethyl (2Z)-3-fluoro-3-phenylprop-2-en-1-yl phosphate; In tetrahydrofuran; at -40 ℃; for 0.5h; Temperature; Reagent/catalyst; Concentration; Overall yield = 43 %; regioselective reaction; Inert atmosphere;

DOI:10.1039/c2ob25718a

Reference yield:

(Z)-3-fluoro-3-phenyl-prop-2-en-1-ol (82754-37-8) → C13H17F (1407518-44-8)

Guidance literature:

Multi-step reaction with 2 steps

1.1: dmap; triethylamine / dichloromethane / 0 - 20 °C / Inert atmosphere

2.1: copper(I) bromide / tetrahydrofuran / 0.33 h / -78 - -10 °C / Inert atmosphere

2.2: 0.5 h / -40 °C

With dmap; triethylamine; copper(I) bromide; In tetrahydrofuran; dichloromethane;

DOI:10.1039/c2ob25718a

upstream raw materials:

ethyl (2Z)-3-fluoro-3-phenylprop-2-enoate

n-butyl magnesium bromide

diethyl (2Z)-3-fluoro-3-phenylprop-2-en-1-yl phosphate

(Z)-3-fluoro-3-phenyl-prop-2-en-1-ol