N-{2-[2-(4-cyanophenyl)-ethyl]-1-methyl-benzimidazol-5-yl}-N-(naphth-1-ylmethyl)-2-chloroacetamide

Base Information

• Chemical Name: N-{2-[2-(4-cyanophenyl)-ethyl]-1-methyl-benzimidazol-5-yl}-N-(naphth-1-ylmethyl)-2-chloroacetamide
• CAS No.: 445378-09-6
• Molecular Formula: C₃₀H₂₅ClN₄O
• Molecular Weight: 493.008

Synonyms:N-{2-[2-(4-cyanophenyl)-ethyl]-1-methyl-benzimidazol-5-yl}-N-(naphth-1-ylmethyl)-2-chloroacetamide

Chemical Property of N-{2-[2-(4-cyanophenyl)-ethyl]-1-methyl-benzimidazol-5-yl}-N-(naphth-1-ylmethyl)-2-chloroacetamide

Chemical Property:

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Technology Process of N-{2-[2-(4-cyanophenyl)-ethyl]-1-methyl-benzimidazol-5-yl}-N-(naphth-1-ylmethyl)-2-chloroacetamide

There total 1 articles about N-{2-[2-(4-cyanophenyl)-ethyl]-1-methyl-benzimidazol-5-yl}-N-(naphth-1-ylmethyl)-2-chloroacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-[2-(4-cyanophenyl)-ethyl]-1-methyl-5-(α-naphthylmethylamino)-benzimidazole (339332-97-7) + chloroacetyl chloride (79-04-9) → N-{2-[2-(4-cyanophenyl)-ethyl]-1-methyl-benzimidazol-5-yl}-N-(naphth-1-ylmethyl)-2-chloroacetamide (445378-09-6)

Guidance literature:

With 4-methyl-morpholine; In dichloromethane;

Reference yield: 92.0%

N-{2-[2-(4-cyanophenyl)-ethyl]-1-methyl-benzimidazol-5-yl}-N-(naphth-1-ylmethyl)-2-chloroacetamide (445378-09-6) → N-{2-[2-(4-cyanophenyl)-ethyl]-1-methyl-benzimidazol-5-yl}-N-(naphth-1-ylmethyl)-2-{4-[N-methyl-N-(3-hydroxypropyl)-amino]-piperid-1-yl}-acetamide (445378-12-1)

Guidance literature:

With potassium carbonate;

Reference yield:

N-{2-[2-(4-cyanophenyl)-ethyl]-1-methyl-benzimidazol-5-yl}-N-(naphth-1-ylmethyl)-2-chloroacetamide (445378-09-6) + 4-phenylamino-1-piperidine → N-{2-[2-(4-Cyanophenyl)-ethyl]-1-methyl-benzimidazol-5-yl}-N-(naphth-1-ylmethyl)-2-(4-phenylamino-piperid-1-yl)-acetamide (445378-10-9)

Guidance literature:

With 4-methyl-morpholine; In N-methyl-acetamide;

upstream raw materials:

2-[2-(4-cyanophenyl)-ethyl]-1-methyl-5-(α-naphthylmethylamino)-benzimidazole

chloroacetyl chloride

Downstream raw materials:

N-{2-[2-(4-cyanophenyl)-ethyl]-1-methyl-benzimidazol-5-yl}-N-(naphth-1-ylmethyl)-2-{4-[N-methyl-N-(3-hydroxypropyl)-amino]-piperid-1-yl}-acetamide

N-{2-[2-(4-Cyanophenyl)-ethyl]-1-methyl-benzimidazol-5-yl}-N-(naphth-1-ylmethyl)-2-(4-phenylamino-piperid-1-yl)-acetamide

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