4-bromo-2-(6-bromo-8-chloro-4-methylquinolin-2-yl)-6-chlorophenylamine

Base Information

Chemical Name:4-bromo-2-(6-bromo-8-chloro-4-methylquinolin-2-yl)-6-chlorophenylamine
CAS No.:1202474-65-4
Molecular Formula:C₁₆H₁₀Br₂Cl₂N₂
Molecular Weight:460.983
Hs Code.:

Synonyms:4-bromo-2-(6-bromo-8-chloro-4-methylquinolin-2-yl)-6-chlorophenylamine

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Chemical Property of 4-bromo-2-(6-bromo-8-chloro-4-methylquinolin-2-yl)-6-chlorophenylamine

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Technology Process of 4-bromo-2-(6-bromo-8-chloro-4-methylquinolin-2-yl)-6-chlorophenylamine

There total 4 articles about 4-bromo-2-(6-bromo-8-chloro-4-methylquinolin-2-yl)-6-chlorophenylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 1202474-59-6
C₈H₅BrClN

: 1202474-65-4
4-bromo-2-(6-bromo-8-chloro-4-methylquinolin-2-yl)-6-chlorophenylamine

Guidance literature:: With gold(III) chloride; silver trifluoromethanesulfonate; In acetonitrile; at 25 ℃; Inert atmosphere; Reflux;
DOI:10.1055/s-0029-1217961

Reference yield:

: 38762-41-3
2-chloro-4-bromoaniline

: 1202474-65-4
4-bromo-2-(6-bromo-8-chloro-4-methylquinolin-2-yl)-6-chlorophenylamine

Guidance literature:: Multi-step reaction with 4 steps

1: [bis(pyridine)iodine]⁺ tetrafluoroborate; tetrafluoroboric acid / dichloromethane / 20 °C

2: bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine / 6 h / 20 °C

3: tetrabutyl ammonium fluoride / tetrahydrofuran / 2 h / 20 °C

4: Au₂(BIPHEP)(NTf₂)₂ / 1,2-dichloro-ethane / 6 h / 25 °C / Inert atmosphere

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; tetrafluoroboric acid; Au₂(BIPHEP)(NTf₂)₂; tetrabutyl ammonium fluoride; [bis(pyridine)iodine]⁺ tetrafluoroborate; triethylamine; In tetrahydrofuran; dichloromethane; 1,2-dichloro-ethane; 1: |Barluenga Lodination / 2: |Sonogashira Cross-Coupling;
DOI:10.1055/s-0035-1561305

Reference yield:

: 4-bromo-6-chloro-2-[2-(trimethylsilyl)ethynyl]aniline

: 1202474-65-4
4-bromo-2-(6-bromo-8-chloro-4-methylquinolin-2-yl)-6-chlorophenylamine

Guidance literature:: Multi-step reaction with 2 steps

1: tetrabutyl ammonium fluoride / tetrahydrofuran / 2 h / 20 °C

2: Au₂(BIPHEP)(NTf₂)₂ / 1,2-dichloro-ethane / 6 h / 25 °C / Inert atmosphere

With Au₂(BIPHEP)(NTf₂)₂; tetrabutyl ammonium fluoride; In tetrahydrofuran; 1,2-dichloro-ethane;
DOI:10.1055/s-0035-1561305