38762-41-3

Basic information

• Product Name: 4-Bromo-2-chloroaniline
• Synonyms: 4-BROMO-2-CHLOROANILINE;4-Bromo-2-chloroaniline 98%;4-BROMO-2-CHLOROANILINE, 98+%;Benzenamine, 4-bromo-2-chloro-;1-Amino-4-bromo-2-chlorobenzene;4-Bromo-2-chloroaniline,99%;4-Bromo-2-chloroanilinev;4-Bromo-2-chloroanil
• CAS NO: 38762-41-3
• Molecular Formula: C₆H₅BrClN
• Molecular Weight: 206.47
• EINECS: 254-118-4
• Product Categories: Amines;blocks;Bromides;Anilines, Aromatic Amines and Nitro Compounds;Benzene series;Anilines, Amides & Amines;Bromine Compounds;Chlorine Compounds;C2 to C6;Nitrogen Compounds;Building Blocks;C6;Chemical Synthesis;Nitrogen Compounds;Organic Building Blocks
• Mol File: 38762-41-3.mol
• Article Data: 28

Chemical Properties

• Melting Point: 70-72 °C(lit.)
• Boiling Point: 241.8 °C at 760 mmHg
• Flash Point: 100 °C
• Appearance: Slightly yellow to light brown/Crystalline Powder
• Density: 1.6567 (rough estimate)
• Vapor Pressure: 0.003mmHg at 25°C
• Refractive Index: 1.5400 (estimate)
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: 1.95±0.10(Predicted)
• BRN: 3117740
• CAS DataBase Reference: 4-Bromo-2-chloroaniline(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Bromo-2-chloroaniline(38762-41-3)
• EPA Substance Registry System: 4-Bromo-2-chloroaniline(38762-41-3)

Safety Data

• Hazard Codes: Xn,T,Xi
• Statements: 20/21/22-20/21
• Safety Statements: 36-23
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 38762-41-3(Hazardous Substances Data)

Usage

Chemical Properties

SLIGHTLY YELLOW TO LIGHT BROWN CRYSTALLINE POWDER

Uses

4-Bromo-2-chloroaniline was used in the peparation of 3,4-dichloro-α-trichloromethylbenzyl alcohol.

InChI:InChI=1/C6H5BrClN/c7-4-1-5(8)3-6(9)2-4/h1-3H,9H2

Upstream product

• 10468-46-9 N-(4-bromophenyl)hydroxylamine 
• 112160-74-4 acetic acid-(2,4,N-trichloro-anilide) 
• 106-40-1 4-bromo-aniline 
• 7647-01-0 hydrogenchloride 
• 7782-50-5 chlorine 
• 67-66-3 chloroform 
• 103-88-8 4-bromoacetanilide 
• 103-84-4 Acetanilid 
• 95-51-2 o-chloroaniline 
• 588-07-8 3-Chloroacetanilide 
• 825-41-2 3-chloro-4-nitroaniline 
• 108-86-1 bromobenzene 
• 586-78-7 para-nitrophenyl bromide 
• 89465-97-4 4-bromo-2-chloro-1-nitrobenzene 

Downstream Products

• 761412-13-9 (4-bromo-2-chloro-phenyl)-carbamic acid ethyl ester 
• 50638-51-2 4-bromo-2-chloro-N,N-dimethylaniline 
• 69065-99-2 (4-bromo-2-chloro-phenyl)-oxalamic acid ethyl ester 
• 721960-43-6 2‐chloro‐4‐(4,4,5,5‐tetramethyl‐1,3,2‐dioxaborolan‐2‐yl)aniline 
• 536746-56-2 2-(4-Bromo-2-chloro-phenylcarbamoyl)-pyrrolidine-1-carboxylic acid tert-butyl ester 
• 1036750-93-2 N-(4-bromo-2-chlorophenyl)-5-chloro-1H-indole-2-carboxamide 
• 78242-79-2 2-chloro-4-cyclopropylaniline 
• 1056465-04-3 (4-bromo-2-chlorophenyl)tetrahydropyranylamine 
• 3460-23-9 N-(4-bromo-2-chlorophenyl)acetamide 
• 1304684-89-6 C₁₄H₈BrClN₂O₂ 
• 1386950-68-0 tert-butyl 4-(4-(bis(tert-butoxycarbonyl)amino)-3-chlorophenyl)piperazine-1-carboxylate 
• 1386951-81-0 tert-butyl 4-(4-(bis(tert-butoxycarbonyl)amino)-3-chlorophenyl)-5,6-dihydropyridine-1(2H)-carboxylate 
• 1386951-82-1 tert-butyl 4-(4-(bis(tert-butoxycarbonyl)amino)-3-chlorophenyl)piperidine-1-carboxylate 
• 1152618-10-4 C₁₁H₁₃BrClNO 

Relevant articles and documents

A Practical Procedure for Regioselective Bromination of Anilines

A highly practical procedure for the preparation of bromoanilines by using copper-catalyzed oxidative bromination has been developed. Treatment of free anilines with readily available NaBr and Na 2S 2O 8in the presence of a catalytic amount of CuSO 4·5H 2O enabled regioselective bromination.

Visible-light-promoted oxidative halogenation of (hetero)arenes

Organic halides are critical building blocks that participate in various cross-coupling reactions. Furthermore, they widely exist as natural products and artificial molecules in drugs with important physiological activities. Although halogenation has been well studied, to the best of our knowledge, studies focussing on sensitive systems (e.g.aryl amines) have not been reported. Herein, we describe a compatible oxidative halogenation of (hetero)arenes with air as the oxidant and halide ions as halide sources under ambient conditions (visible light, air, aqueous system, room temperature, and normal pressure). Moreover, this protocol is practically feasible for gram-scale synthesis, showing potential for industrial application.

Sodium sulfate-hydrogen peroxide-sodium chloride adduct: selective protocol for the oxidative bromination, iodination and temperature dependent oxidation of sulfides to sulfoxides and sulfones

The regioselective bromination and iodination of unprotected aromatic primary amines using enclathrated hydrogen peroxide as an oxidant under mild conditions has been developed, in which potassium bromide (KBr) and potassium iodide (KI) were used as brominating and iodinating agents, respectively. The adduct shows not only regioselectivity for para- or ortho-isomers but also a remarkable chemoselectivity for monobromination. Selective oxidation of sulfides to sulfoxides and sulfones has also been studied and good to excellent yields of the desired products were obtained. Acetic acid was found to be the solvent of choice for these reactions. This simple method represents an ecologically benign and alternative pathway for the oxidative halogenation of anilines and the oxidation of sulfides to sulfoxides and sulfones.