Imidazo[1,2-a]pyridin-5-ylamine

Base Information

• Chemical Name: Imidazo[1,2-a]pyridin-5-ylamine
• CAS No.: 66358-23-4
• Molecular Formula: C7H7N3
• Molecular Weight: 133.153
• Hs Code.: 2933990090
• Mol file: 66358-23-4.mol

Synonyms:NSC 305200;Imidazo[1,2-a]pyridin-5-ylamine;

Chemical Property of Imidazo[1,2-a]pyridin-5-ylamine

Chemical Property:

• Melting Point: 156-158 °C
• Refractive Index: 1.696
• PKA: 8.98±0.50(Predicted)
• PSA: 43.32000
• Density: 1.32 g/cm³
• LogP: 1.49770
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature

Purity/Quality:

99%, ^*data from raw suppliers

Imidazo[1,2-a]pyridin-5-amine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Imidazo[1,2-a]pyridin-5-ylamine

There total 1 articles about Imidazo[1,2-a]pyridin-5-ylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

2-chloroethanal (107-20-0) + 2.6-diaminopyridine (141-86-6) → 5-aminoimidazo<1,2-a>pyridine (66358-23-4)

Guidance literature:

2-chloroethanal; 2.6-diaminopyridine; In ethanol; at 75 ℃; for 1h;

With sodium hydrogencarbonate; In water; ethyl acetate;

Reference yield: 48.0%

5-aminoimidazo<1,2-a>pyridine (66358-23-4) + triphenylphosphine (603-35-0) → 5-(triphenylphosphoranylidene)aminoimidazo-[1,2-a]pyridine

Guidance literature:

With tetrachloromethane; triethylamine; In acetonitrile; at 20 ℃; for 24h;

DOI:10.1016/S0040-4020(01)01141-3

Reference yield: 46.0%

di(succinimido) carbonate (74124-79-1) + 1-[3-(4-chloro-phenoxy)-benzyl]-piperazine hydrochloride + 5-aminoimidazo<1,2-a>pyridine (66358-23-4) → 4-[3-(4-chloro-phenoxy)-benzyl]-piperazine-1-carboxylic acid imidazo[1,2-a]pyridin-5-ylamide (1230020-10-6)

Guidance literature:

di(succinimido) carbonate; 5-aminoimidazo<1,2-a>pyridine; With dmap; In dichloromethane; at 20 ℃; for 6h; Inert atmosphere;

1-[3-(4-chloro-phenoxy)-benzyl]-piperazine hydrochloride; With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 16h; Inert atmosphere;

upstream raw materials:

2-chloroethanal

2.6-diaminopyridine

Downstream raw materials:

imidazo[1,2-a]pyridin-5-ol

5-tert-butoxycarbonylaminoimidazo[1,2-a]pyridine

4-[3-(4-chloro-phenoxy)-benzyl]-piperazine-1-carboxylic acid imidazo[1,2-a]pyridin-5-ylamide

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