4-[3-(4-chloro-phenoxy)-benzyl]-piperazine-1-carboxylic acid imidazo[1,2-a]pyridin-5-ylamide

Base Information

Chemical Name:4-[3-(4-chloro-phenoxy)-benzyl]-piperazine-1-carboxylic acid imidazo[1,2-a]pyridin-5-ylamide
CAS No.:1230020-10-6
Molecular Formula:C₂₅H₂₄ClN₅O₂
Molecular Weight:461.951
Hs Code.:

Synonyms:4-[3-(4-chloro-phenoxy)-benzyl]-piperazine-1-carboxylic acid imidazo[1,2-a]pyridin-5-ylamide

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Chemical Property of 4-[3-(4-chloro-phenoxy)-benzyl]-piperazine-1-carboxylic acid imidazo[1,2-a]pyridin-5-ylamide

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Technology Process of 4-[3-(4-chloro-phenoxy)-benzyl]-piperazine-1-carboxylic acid imidazo[1,2-a]pyridin-5-ylamide

There total 6 articles about 4-[3-(4-chloro-phenoxy)-benzyl]-piperazine-1-carboxylic acid imidazo[1,2-a]pyridin-5-ylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

: 74124-79-1
di(succinimido) carbonate

: 1-[3-(4-chloro-phenoxy)-benzyl]-piperazine hydrochloride

: 66358-23-4
5-aminoimidazo<1,2-a>pyridine

: 1230020-10-6
4-[3-(4-chloro-phenoxy)-benzyl]-piperazine-1-carboxylic acid imidazo[1,2-a]pyridin-5-ylamide

Guidance literature:: di(succinimido) carbonate; 5-aminoimidazo<1,2-a>pyridine; With dmap; In dichloromethane; at 20 ℃; for 6h; Inert atmosphere;

1-[3-(4-chloro-phenoxy)-benzyl]-piperazine hydrochloride; With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 16h; Inert atmosphere;

Reference yield:

: 1230021-77-8
tert-butyl 4-(3-(4-chlorophenoxy)benzyl)piperazine-1-carboxylate

: 1230020-10-6
4-[3-(4-chloro-phenoxy)-benzyl]-piperazine-1-carboxylic acid imidazo[1,2-a]pyridin-5-ylamide

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogenchloride / dichloromethane; 1,4-dioxane / 23 h / 20 °C

2: N-ethyl-N,N-diisopropylamine

With hydrogenchloride; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; dichloromethane;
DOI:10.1016/j.bmcl.2012.10.076

Reference yield:

: 69770-20-3
3-(4-chlorophenoxy)benzaldehyde

: 1230020-10-6
4-[3-(4-chloro-phenoxy)-benzyl]-piperazine-1-carboxylic acid imidazo[1,2-a]pyridin-5-ylamide

Guidance literature:: Multi-step reaction with 3 steps

1: sodium tris(acetoxy)borohydride / dichloromethane / 23 h / 20 °C

2: hydrogenchloride / dichloromethane; 1,4-dioxane / 23 h / 20 °C

3: N-ethyl-N,N-diisopropylamine

With hydrogenchloride; sodium tris(acetoxy)borohydride; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; dichloromethane;
DOI:10.1016/j.bmcl.2012.10.076