(αR)-α-[[[5-(4-trifluoromethylphenyl)-thien-2-yl]sulfonyl]amino]-4-piperidineacetic acid hydrochloride

Base Information

Chemical Name:(αR)-α-[[[5-(4-trifluoromethylphenyl)-thien-2-yl]sulfonyl]amino]-4-piperidineacetic acid hydrochloride
CAS No.:1098299-17-2
Molecular Formula:C₁₈H₁₉F₃N₂O₄S₂*ClH
Molecular Weight:484.948
Hs Code.:

Synonyms:(αR)-α-[[[5-(4-trifluoromethylphenyl)-thien-2-yl]sulfonyl]amino]-4-piperidineacetic acid hydrochloride

Suppliers and Price of (αR)-α-[[[5-(4-trifluoromethylphenyl)-thien-2-yl]sulfonyl]amino]-4-piperidineacetic acid hydrochloride

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (αR)-α-[[[5-(4-trifluoromethylphenyl)-thien-2-yl]sulfonyl]amino]-4-piperidineacetic acid hydrochloride

Chemical Property:

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Technology Process of (αR)-α-[[[5-(4-trifluoromethylphenyl)-thien-2-yl]sulfonyl]amino]-4-piperidineacetic acid hydrochloride

There total 1 articles about (αR)-α-[[[5-(4-trifluoromethylphenyl)-thien-2-yl]sulfonyl]amino]-4-piperidineacetic acid hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 458560-10-6
(αR)-1-BOC-α-[[[5-(4-trifluoromethyl-phenyl)-2-thienyl]sulfonyl]amino]4-piperidineacetic acid

: 1098299-17-2
(αR)-α-[[[5-(4-trifluoromethylphenyl)-thien-2-yl]sulfonyl]amino]-4-piperidineacetic acid hydrochloride

Guidance literature:: With hydrogenchloride; In dichloromethane; at 0 ℃; for 0.25h;

Reference yield:

: 1098299-17-2
(αR)-α-[[[5-(4-trifluoromethylphenyl)-thien-2-yl]sulfonyl]amino]-4-piperidineacetic acid hydrochloride

: 543-27-1
isobutyl chloroformate

: (αR)-1-[(2-methylpropoxy)carbonyl]-α-[[[5-(4-trifluoromethylphenyl)-2-thienyl]sulfonyl]amino]4-piperidineacetic

Guidance literature:: (αR)-α-[[[5-(4-trifluoromethylphenyl)-thien-2-yl]sulfonyl]amino]-4-piperidineacetic acid hydrochloride; With N,O-bis-(trimethylsilyl)-acetamide; In tetrahydrofuran; at 20 ℃; for 0.5h;

isobutyl chloroformate; In tetrahydrofuran; for 14h;

With sodium hydrogencarbonate; In water;

Reference yield:

: 1098299-17-2
(αR)-α-[[[5-(4-trifluoromethylphenyl)-thien-2-yl]sulfonyl]amino]-4-piperidineacetic acid hydrochloride

: 108-23-6
isopropyl chloroformate

: 458559-22-3
4-{(R)-carboxy-[5-(4'-trifluoromethylphenyl)-thiophene-2-sulfonylamino]-methyl}-piperidine-1-carboxylic acid iso-propyl ester

Guidance literature:: (αR)-α-[[[5-(4-trifluoromethylphenyl)-thien-2-yl]sulfonyl]amino]-4-piperidineacetic acid hydrochloride; With N,O-bis-(trimethylsilyl)-acetamide; In tetrahydrofuran;

isopropyl chloroformate; In tetrahydrofuran; toluene;
DOI:10.1021/jm801394m