(R)-1-(4-chlorophenyl)-7-methoxy-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole

Base Information

Chemical Name:(R)-1-(4-chlorophenyl)-7-methoxy-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole
CAS No.:1120500-34-6
Molecular Formula:C₁₈H₁₇ClN₂O
Molecular Weight:312.799
Hs Code.:

Synonyms:(R)-1-(4-chlorophenyl)-7-methoxy-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-1-(4-chlorophenyl)-7-methoxy-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole

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Technology Process of (R)-1-(4-chlorophenyl)-7-methoxy-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole

There total 4 articles about (R)-1-(4-chlorophenyl)-7-methoxy-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 104-88-1
4-chlorobenzaldehyde

: 3610-36-4
2-(6-methoxy-1H-indol-3-yl)ethanamine

: 1120500-34-6
(R)-1-(4-chlorophenyl)-7-methoxy-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole

Guidance literature:: With 1,1'-(2S,2'S)-1,1'-(4,10-dimethyl-1,4,7,10-tetraazacyclododecane-1,7-diyl)bis(3-methyl-1-oxobutane-2,1-diyl)bis(3-(3,5-bis(trifluoromethyl)phenyl)thiourea); 4-methoxybenzoic acid; In toluene; at 20 ℃; for 72h; enantioselective reaction;
DOI:10.1002/ejoc.202001501

Reference yield: 91.0%

: 1120500-26-6
C₁₈H₁₇ClN₂O

: 1120500-34-6
(R)-1-(4-chlorophenyl)-7-methoxy-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole

Guidance literature:: With (S)-N-benzyl-2-(3-(3,5-bis(trifluoromethyl)phenyl)thioureido)-N,3-dimethylbutanamide; benzoic acid; In toluene; at 23 ℃; for 18h; optical yield given as %ee; enantioselective reaction; Inert atmosphere;
DOI:10.1021/ol802887h

Reference yield:

: 1120500-26-6
C₁₈H₁₇ClN₂O

: 1120500-34-6
(R)-1-(4-chlorophenyl)-7-methoxy-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole

: 1120500-32-4
(S)-1-(4-chlorophenyl)-7-methoxy-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole

Guidance literature:: With C₁₉H₂₅F₆N₃O₂S; acetic acid; In toluene; at 23 ℃; for 18h; optical yield given as %ee; enantioselective reaction; Inert atmosphere;
DOI:10.1021/ol802887h