tert-butyl (R)-1-(4-chlorophenyl)-7-methoxy-1,3,4,9-tetrahydro-2H-pyrido[3,4-b]indole-2-carboxylate

Base Information

Chemical Name:tert-butyl (R)-1-(4-chlorophenyl)-7-methoxy-1,3,4,9-tetrahydro-2H-pyrido[3,4-b]indole-2-carboxylate
CAS No.:1120500-72-2
Molecular Formula:C₂₃H₂₅ClN₂O₃
Molecular Weight:412.916
Hs Code.:

Synonyms:tert-butyl (R)-1-(4-chlorophenyl)-7-methoxy-1,3,4,9-tetrahydro-2H-pyrido[3,4-b]indole-2-carboxylate

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Chemical Property of tert-butyl (R)-1-(4-chlorophenyl)-7-methoxy-1,3,4,9-tetrahydro-2H-pyrido[3,4-b]indole-2-carboxylate

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Technology Process of tert-butyl (R)-1-(4-chlorophenyl)-7-methoxy-1,3,4,9-tetrahydro-2H-pyrido[3,4-b]indole-2-carboxylate

There total 3 articles about tert-butyl (R)-1-(4-chlorophenyl)-7-methoxy-1,3,4,9-tetrahydro-2H-pyrido[3,4-b]indole-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 24424-99-5
di-tert-butyl dicarbonate

: 1120500-34-6
(R)-1-(4-chlorophenyl)-7-methoxy-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole

: 1120500-72-2
tert-butyl (R)-1-(4-chlorophenyl)-7-methoxy-1,3,4,9-tetrahydro-2H-pyrido[3,4-b]indole-2-carboxylate

Guidance literature:: With sodium hydrogencarbonate; In water; ethyl acetate; at 20 ℃; for 2h;
DOI:10.1002/ejoc.202001501

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 1-(4-chlorophenyl)-7-methoxy-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole

: tert-butyl (S)-1-(4-chlorophenyl)-7-methoxy-3,4-dihydro-1H-pyrido[3,4-b]indole-2(9H)-carboxylate

: 1120500-72-2
tert-butyl (R)-1-(4-chlorophenyl)-7-methoxy-1,3,4,9-tetrahydro-2H-pyrido[3,4-b]indole-2-carboxylate

Guidance literature:: With sodium hydrogencarbonate; In water; ethyl acetate; at 23 ℃; for 1.5h; Inert atmosphere;
DOI:10.1021/jacs.7b06811

Reference yield:

: 104-88-1
4-chlorobenzaldehyde

: 3610-36-4
2-(6-methoxy-1H-indol-3-yl)ethanamine

: 1120500-72-2
tert-butyl (R)-1-(4-chlorophenyl)-7-methoxy-1,3,4,9-tetrahydro-2H-pyrido[3,4-b]indole-2-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: 1,1'-(2S,2'S)-1,1'-(4,10-dimethyl-1,4,7,10-tetraazacyclododecane-1,7-diyl)bis(3,3-dimethyl-1-oxobutane-2,1-diyl)bis(3-(3,5 bis(trifluoromethyl)phenyl)urea); 4-methoxybenzoic acid / toluene / 72 h / 20 °C

2: sodium hydrogencarbonate / water; ethyl acetate / 2 h / 20 °C

With 1,1'-(2S,2'S)-1,1'-(4,10-dimethyl-1,4,7,10-tetraazacyclododecane-1,7-diyl)bis(3,3-dimethyl-1-oxobutane-2,1-diyl)bis(3-(3,5 bis(trifluoromethyl)phenyl)urea); sodium hydrogencarbonate; 4-methoxybenzoic acid; In water; ethyl acetate; toluene; 1: |Pictet-Spengler Synthesis;
DOI:10.1002/ejoc.202001501