2-[(3S,4S)-1-[(4-fluorophenyl)methyl]-4-methylpyrrolidin-3-yl]-7-tetrahydropyran-4-yl-3H-imidazo[5,1-f][1,2,4]triazin-4-one

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Chemical Name:2-[(3S,4S)-1-[(4-fluorophenyl)methyl]-4-methylpyrrolidin-3-yl]-7-tetrahydropyran-4-yl-3H-imidazo[5,1-f][1,2,4]triazin-4-one
CAS No.:1448726-22-4
Molecular Formula:C₂₂H₂₆FN₅O₂
Molecular Weight:411.479
Hs Code.:

Synonyms:2-[(3S,4S)-1-[(4-fluorophenyl)methyl]-4-methylpyrrolidin-3-yl]-7-tetrahydropyran-4-yl-3H-imidazo[5,1-f][1,2,4]triazin-4-one

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Chemical Property of 2-[(3S,4S)-1-[(4-fluorophenyl)methyl]-4-methylpyrrolidin-3-yl]-7-tetrahydropyran-4-yl-3H-imidazo[5,1-f][1,2,4]triazin-4-one

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Technology Process of 2-[(3S,4S)-1-[(4-fluorophenyl)methyl]-4-methylpyrrolidin-3-yl]-7-tetrahydropyran-4-yl-3H-imidazo[5,1-f][1,2,4]triazin-4-one

There total 8 articles about 2-[(3S,4S)-1-[(4-fluorophenyl)methyl]-4-methylpyrrolidin-3-yl]-7-tetrahydropyran-4-yl-3H-imidazo[5,1-f][1,2,4]triazin-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 30.0%

: 2-[1-(4-fluoro-benzyl)-4-methyl-pyrrolidin-3-yl]-7-(tetrahydro-pyran-4-yl)-3H-imidazo[5,1-f][1,2,4]triazin-4-one

: 1448726-22-4
2-[(3S,4S)-1-[(4-fluorophenyl)methyl]-4-methylpyrrolidin-3-yl]-7-tetrahydropyran-4-yl-3H-imidazo[5,1-f][1,2,4]triazin-4-one

: 1448726-23-5
2-[(3R,4R)-1-[(4-fluorophenyl)methyl]-4-methylpyrrolidin-3-yl]-7-tetrahydropyran-4-yl-3H-imidazo[5,1-f][1,2,4]triazin-4-one

Guidance literature:: With chiralcel OJ-H; In ethanol; hexane; Resolution of racemate;

Reference yield: 30.0%

: 2-[1-[(4-fluorophenyl)methyl]-4-methylpyrrolidin-3-yl]-7-tetrahydropyran-4-yl-3H-imidazo[5,1-f][1,2,4]triazin-4-one

: 1448726-22-4
2-[(3S,4S)-1-[(4-fluorophenyl)methyl]-4-methylpyrrolidin-3-yl]-7-tetrahydropyran-4-yl-3H-imidazo[5,1-f][1,2,4]triazin-4-one

: 1448726-23-5
2-[(3R,4R)-1-[(4-fluorophenyl)methyl]-4-methylpyrrolidin-3-yl]-7-tetrahydropyran-4-yl-3H-imidazo[5,1-f][1,2,4]triazin-4-one

Guidance literature:: With chiralcel OJ-H; In ethanol; hexane; Resolution of racemate;

Reference yield:

: 1448717-98-3
2-(1-benzyl-4-methyl-pyrrolidin-3-yl)-7-iodo-3H-imidazo[5,1-f][1,2,4]triazin-4-one

: 1448726-22-4
2-[(3S,4S)-1-[(4-fluorophenyl)methyl]-4-methylpyrrolidin-3-yl]-7-tetrahydropyran-4-yl-3H-imidazo[5,1-f][1,2,4]triazin-4-one

: 1448726-23-5
2-[(3R,4R)-1-[(4-fluorophenyl)methyl]-4-methylpyrrolidin-3-yl]-7-tetrahydropyran-4-yl-3H-imidazo[5,1-f][1,2,4]triazin-4-one

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium phosphate; palladium bis[bis(diphenylphosphino)ferrocene] dichloride; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / N,N-dimethyl-formamide; water / 1 h / 150 °C / Inert atmosphere; Microwave irradiation

2.1: potassium acetate; palladium 10% on activated carbon; hydrogen / methanol / 50 °C

3.1: hydrogenchloride / dichloromethane; diethyl ether / 2 h / 20 °C

4.1: acetic acid / 1,2-dichloro-ethane / 1 h / 20 °C

4.2: 16 h / 20 °C

5.1: chiralcel OJ-H / hexane; ethanol / Resolution of racemate

With hydrogenchloride; potassium phosphate; palladium bis[bis(diphenylphosphino)ferrocene] dichloride; palladium 10% on activated carbon; hydrogen; potassium acetate; acetic acid; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In methanol; diethyl ether; ethanol; hexane; dichloromethane; water; 1,2-dichloro-ethane; N,N-dimethyl-formamide;