2-(1-benzyl-4-methyl-pyrrolidin-3-yl)-7-(3,6-dihydro-2H-pyran-4-yl)-3H-imidazo[5,1-f][1,2,4]triazin-4-one

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Chemical Name:2-(1-benzyl-4-methyl-pyrrolidin-3-yl)-7-(3,6-dihydro-2H-pyran-4-yl)-3H-imidazo[5,1-f][1,2,4]triazin-4-one
CAS No.:1448717-75-6
Molecular Formula:C₂₂H₂₅N₅O₂
Molecular Weight:391.473
Hs Code.:

Synonyms:2-(1-benzyl-4-methyl-pyrrolidin-3-yl)-7-(3,6-dihydro-2H-pyran-4-yl)-3H-imidazo[5,1-f][1,2,4]triazin-4-one

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Chemical Property of 2-(1-benzyl-4-methyl-pyrrolidin-3-yl)-7-(3,6-dihydro-2H-pyran-4-yl)-3H-imidazo[5,1-f][1,2,4]triazin-4-one

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Technology Process of 2-(1-benzyl-4-methyl-pyrrolidin-3-yl)-7-(3,6-dihydro-2H-pyran-4-yl)-3H-imidazo[5,1-f][1,2,4]triazin-4-one

There total 5 articles about 2-(1-benzyl-4-methyl-pyrrolidin-3-yl)-7-(3,6-dihydro-2H-pyran-4-yl)-3H-imidazo[5,1-f][1,2,4]triazin-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: 1448717-98-3
2-(1-benzyl-4-methyl-pyrrolidin-3-yl)-7-iodo-3H-imidazo[5,1-f][1,2,4]triazin-4-one

: 287944-16-5
4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-3,6-dihydro-2H-pyran

: 1448717-75-6
2-(1-benzyl-4-methyl-pyrrolidin-3-yl)-7-(3,6-dihydro-2H-pyran-4-yl)-3H-imidazo[5,1-f][1,2,4]triazin-4-one

Guidance literature:: With potassium phosphate; palladium bis[bis(diphenylphosphino)ferrocene] dichloride; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In water; N,N-dimethyl-formamide; at 150 ℃; for 1h; Inert atmosphere; Microwave irradiation;

Reference yield:

: 1448717-96-1
3-[(1-benzyl-4-methyl-pyrrolidine-3-carbonyl)-amino]-3H-imidazole-4-carboxylic acid methyl ester

: 1448717-75-6
2-(1-benzyl-4-methyl-pyrrolidin-3-yl)-7-(3,6-dihydro-2H-pyran-4-yl)-3H-imidazo[5,1-f][1,2,4]triazin-4-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: ammonium acetate; ammonium hydroxide / methanol / 48 h / 130 °C / Sealed tube

2.1: n-butyllithium / tetrahydrofuran / 0.5 h / -78 - -45 °C

2.2: 2 h / -78 - 0 °C

3.1: potassium phosphate; palladium bis[bis(diphenylphosphino)ferrocene] dichloride; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / N,N-dimethyl-formamide; water / 1 h / 150 °C / Inert atmosphere; Microwave irradiation

With ammonium hydroxide; potassium phosphate; n-butyllithium; palladium bis[bis(diphenylphosphino)ferrocene] dichloride; ammonium acetate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide;

Reference yield:

: 1448718-30-6
C₁₃H₁₆ClNO

: 1448717-75-6
2-(1-benzyl-4-methyl-pyrrolidin-3-yl)-7-(3,6-dihydro-2H-pyran-4-yl)-3H-imidazo[5,1-f][1,2,4]triazin-4-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: triethylamine / dichloromethane / 8 h / 0 - 20 °C

2.1: ammonium acetate; ammonium hydroxide / methanol / 48 h / 130 °C / Sealed tube

3.1: n-butyllithium / tetrahydrofuran / 0.5 h / -78 - -45 °C

3.2: 2 h / -78 - 0 °C

4.1: potassium phosphate; palladium bis[bis(diphenylphosphino)ferrocene] dichloride; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / N,N-dimethyl-formamide; water / 1 h / 150 °C / Inert atmosphere; Microwave irradiation

With ammonium hydroxide; potassium phosphate; n-butyllithium; palladium bis[bis(diphenylphosphino)ferrocene] dichloride; ammonium acetate; triethylamine; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide;