benzyl N-[N-(N-benzyloxycarbonyl-glycyl)-L-prolyl]-L-glutamate α-N,N-dimethylamide

Base Information

Chemical Name:benzyl N-[N-(N-benzyloxycarbonyl-glycyl)-L-prolyl]-L-glutamate α-N,N-dimethylamide
CAS No.:841233-82-7
Molecular Formula:C₂₉H₃₆N₄O₇
Molecular Weight:552.627
Hs Code.:

Synonyms:benzyl N-[N-(N-benzyloxycarbonyl-glycyl)-L-prolyl]-L-glutamate α-N,N-dimethylamide

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Chemical Property of benzyl N-[N-(N-benzyloxycarbonyl-glycyl)-L-prolyl]-L-glutamate α-N,N-dimethylamide

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Technology Process of benzyl N-[N-(N-benzyloxycarbonyl-glycyl)-L-prolyl]-L-glutamate α-N,N-dimethylamide

There total 4 articles about benzyl N-[N-(N-benzyloxycarbonyl-glycyl)-L-prolyl]-L-glutamate α-N,N-dimethylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 25.0%

: benzyl L-γ-glutamate α-N,N-dimethylamide trifluoroacetic acid salt

: 1160-54-9
(2S)-1-(2-[[(benzyloxy)carbonyl]amino]acetyl)tetrahydro-1H-pyrrole-2-carboxylic acid

: 841233-82-7
benzyl N-[N-(N-benzyloxycarbonyl-glycyl)-L-prolyl]-L-glutamate α-N,N-dimethylamide

Guidance literature:: With bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 20h;
DOI:10.1016/j.bmc.2004.10.005

Reference yield:

: 1138-80-3
N-(Benzyloxycarbonyl)glycine

: 841233-82-7
benzyl N-[N-(N-benzyloxycarbonyl-glycyl)-L-prolyl]-L-glutamate α-N,N-dimethylamide

Guidance literature:: Multi-step reaction with 3 steps

1: 0.88 g / 1,3-dicyclohexylcarbodiimide; triethylamine / CH₂Cl₂ / 18 h / 20 °C

2: NaOH / H₂O; dioxane / 21 h / 20 °C

3: 25 percent / diisopropylethylamine; bis(2-oxo-3-oxazolidinyl)phosphinic chloride / CH₂Cl₂ / 20 h / 20 °C

With sodium hydroxide; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; triethylamine; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; In 1,4-dioxane; dichloromethane; water;
DOI:10.1016/j.bmc.2004.10.005

Reference yield:

: 66449-90-9
(2S)-N-(N-Benzyloxycarbonylglycyl)proline methyl ester

: 841233-82-7
benzyl N-[N-(N-benzyloxycarbonyl-glycyl)-L-prolyl]-L-glutamate α-N,N-dimethylamide

Guidance literature:: Multi-step reaction with 2 steps

1: NaOH / H₂O; dioxane / 21 h / 20 °C

2: 25 percent / diisopropylethylamine; bis(2-oxo-3-oxazolidinyl)phosphinic chloride / CH₂Cl₂ / 20 h / 20 °C

With sodium hydroxide; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; dichloromethane; water;
DOI:10.1016/j.bmc.2004.10.005