2-(2-tert-butylphenoxy)-6-methylbenzoic acid isopropyl ester

Base Information

• Chemical Name: 2-(2-tert-butylphenoxy)-6-methylbenzoic acid isopropyl ester
• CAS No.: 1338235-73-6
• Molecular Formula: C₂₁H₂₆O₃
• Molecular Weight: 326.436
• Mol file: 1338235-73-6.mol

Synonyms:2-(2-tert-butylphenoxy)-6-methylbenzoic acid isopropyl ester

Chemical Property of 2-(2-tert-butylphenoxy)-6-methylbenzoic acid isopropyl ester

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of 2-(2-tert-butylphenoxy)-6-methylbenzoic acid isopropyl ester

There total 2 articles about 2-(2-tert-butylphenoxy)-6-methylbenzoic acid isopropyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

2-tert-Butylphenol (88-18-6) + 2-bromo-6-methylbenzoic acid isopropyl ester (1338235-72-5) → 2-(2-tert-butylphenoxy)-6-methylbenzoic acid isopropyl ester (1338235-73-6)

Guidance literature:

With copper (I) trifluoromethane sulfonate benzene; caesium carbonate; ethyl acetate; In toluene; at 110 ℃; for 60h; Inert atmosphere;

DOI:10.1039/c1ob05862b

Reference yield:

2-bromo-6-methylbenzoic acid (90259-31-7) → 2-(2-tert-butylphenoxy)-6-methylbenzoic acid isopropyl ester (1338235-73-6)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate / N,N-dimethyl-formamide / 16 h / 20 - 50 °C

2: copper (I) trifluoromethane sulfonate benzene; caesium carbonate; ethyl acetate / toluene / 60 h / 110 °C / Inert atmosphere

With copper (I) trifluoromethane sulfonate benzene; potassium carbonate; caesium carbonate; ethyl acetate; In N,N-dimethyl-formamide; toluene; 2: Ullmann condensation;

DOI:10.1039/c1ob05862b

upstream raw materials:

2-tert-Butylphenol

2-bromo-6-methylbenzoic acid isopropyl ester

2-bromo-6-methylbenzoic acid