(S)-1-(4-(7,7-dimethyl-4-(3-methylmorpholino)-5,7-dihydrofuro[3,4-d]pyrimidin-2-yl)phenyl)-3-ethylurea

Base Information

Chemical Name:(S)-1-(4-(7,7-dimethyl-4-(3-methylmorpholino)-5,7-dihydrofuro[3,4-d]pyrimidin-2-yl)phenyl)-3-ethylurea
CAS No.:1260088-69-4
Molecular Formula:C₂₂H₂₉N₅O₃
Molecular Weight:411.504
Hs Code.:

Synonyms:(S)-1-(4-(7,7-dimethyl-4-(3-methylmorpholino)-5,7-dihydrofuro[3,4-d]pyrimidin-2-yl)phenyl)-3-ethylurea

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Chemical Property of (S)-1-(4-(7,7-dimethyl-4-(3-methylmorpholino)-5,7-dihydrofuro[3,4-d]pyrimidin-2-yl)phenyl)-3-ethylurea

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Technology Process of (S)-1-(4-(7,7-dimethyl-4-(3-methylmorpholino)-5,7-dihydrofuro[3,4-d]pyrimidin-2-yl)phenyl)-3-ethylurea

There total 5 articles about (S)-1-(4-(7,7-dimethyl-4-(3-methylmorpholino)-5,7-dihydrofuro[3,4-d]pyrimidin-2-yl)phenyl)-3-ethylurea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 874291-00-6
1-ethyl-3-[4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)phenyl]urea

: 1260088-73-0
(S)-2-chloro-7,7-dimethyl-4-(3-methylmorpholino)-5,7-dihydrofuro[3,4-d]pyrimidine

: 1260088-69-4
(S)-1-(4-(7,7-dimethyl-4-(3-methylmorpholino)-5,7-dihydrofuro[3,4-d]pyrimidin-2-yl)phenyl)-3-ethylurea

Guidance literature:: With potassium acetate; sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In acetonitrile; at 110 ℃; for 0.5h; Microwave irradiation;

Reference yield:

: 1260088-70-7
methyl 4-amino-5,5-dimethyl-2,5-dihydrofuran-3-carboxylate

: 1260088-69-4
(S)-1-(4-(7,7-dimethyl-4-(3-methylmorpholino)-5,7-dihydrofuro[3,4-d]pyrimidin-2-yl)phenyl)-3-ethylurea

Guidance literature:: Multi-step reaction with 4 steps

1.1: pyridine / 1,2-dichloro-ethane; toluene / 3 h / 0 °C

1.2: 19 h / 0 - 50 °C

2.1: trichlorophosphate / 1,2-dichloro-ethane / 20 h / 80 °C

3.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 15 h / 0 °C

4.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium acetate; sodium carbonate / acetonitrile / 0.5 h / 110 °C / Microwave irradiation

With pyridine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium acetate; sodium carbonate; N-ethyl-N,N-diisopropylamine; trichlorophosphate; In 1,2-dichloro-ethane; N,N-dimethyl-formamide; toluene; acetonitrile;
DOI:10.1021/jm200215y

Reference yield:

: 1260088-71-8
7,7-dimethyl-5,7-dihydrofuro[3,4-d]pyrimidine-2,4(1H,3H)-dione

: 1260088-69-4
(S)-1-(4-(7,7-dimethyl-4-(3-methylmorpholino)-5,7-dihydrofuro[3,4-d]pyrimidin-2-yl)phenyl)-3-ethylurea

Guidance literature:: Multi-step reaction with 3 steps

1: trichlorophosphate / 1,2-dichloro-ethane / 20 h / 80 °C

2: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 15 h / 0 °C

3: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium acetate; sodium carbonate / acetonitrile / 0.5 h / 110 °C / Microwave irradiation

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium acetate; sodium carbonate; N-ethyl-N,N-diisopropylamine; trichlorophosphate; In 1,2-dichloro-ethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jm200215y