N-[2-(5-tert-butyl-1,3,4-oxadiazol-2-yl)-1-(methylethyl)-2-oxoethyl]-2-{6-oxo-2-phenyl-5-[(phenylmethoxy)carbamido]hydropyrimidinyl}acetamide

Base Information

Chemical Name:N-[2-(5-tert-butyl-1,3,4-oxadiazol-2-yl)-1-(methylethyl)-2-oxoethyl]-2-{6-oxo-2-phenyl-5-[(phenylmethoxy)carbamido]hydropyrimidinyl}acetamide
CAS No.:293329-65-4
Molecular Formula:C₃₁H₃₄N₆O₆
Molecular Weight:586.648
Hs Code.:

Synonyms:N-[2-(5-tert-butyl-1,3,4-oxadiazol-2-yl)-1-(methylethyl)-2-oxoethyl]-2-{6-oxo-2-phenyl-5-[(phenylmethoxy)carbamido]hydropyrimidinyl}acetamide

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Chemical Property of N-[2-(5-tert-butyl-1,3,4-oxadiazol-2-yl)-1-(methylethyl)-2-oxoethyl]-2-{6-oxo-2-phenyl-5-[(phenylmethoxy)carbamido]hydropyrimidinyl}acetamide

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Technology Process of N-[2-(5-tert-butyl-1,3,4-oxadiazol-2-yl)-1-(methylethyl)-2-oxoethyl]-2-{6-oxo-2-phenyl-5-[(phenylmethoxy)carbamido]hydropyrimidinyl}acetamide

There total 8 articles about N-[2-(5-tert-butyl-1,3,4-oxadiazol-2-yl)-1-(methylethyl)-2-oxoethyl]-2-{6-oxo-2-phenyl-5-[(phenylmethoxy)carbamido]hydropyrimidinyl}acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 337969-29-6
N-[(1S)-2-(5-tert-butyl-1,3,4-oxadiazol-2-yl)-2-hydroxy-1-(methylethyl)ethyl]-2-{6-oxo-2-phenyl-5-[(phenylmethoxy)carbonylamino]hydropyrimidinyl}acetamide

: 293329-65-4
N-[2-(5-tert-butyl-1,3,4-oxadiazol-2-yl)-1-(methylethyl)-2-oxoethyl]-2-{6-oxo-2-phenyl-5-[(phenylmethoxy)carbamido]hydropyrimidinyl}acetamide

Guidance literature:: With oxalyl dichloride; dimethyl sulfoxide; In dichloromethane; at -70 ℃; for 2h;
DOI:10.1021/jm000410y

Reference yield:

: (1RS)-1-(5-(t-Butyl)-1,3,4-oxadiazol-2-ylcarbonyl)-2-methylpropylamine Hydrochloride

: 1634-04-4
tert-butyl methyl ether

: 541-41-3
chloroformic acid ethyl ester

: 148747-59-5
5-benzyloxycarbonylamino-6-oxo-2-phenyl-1,6-dihydropyrimidin-1-ylmethylcarboxylic acid

: 293329-65-4
N-[2-(5-tert-butyl-1,3,4-oxadiazol-2-yl)-1-(methylethyl)-2-oxoethyl]-2-{6-oxo-2-phenyl-5-[(phenylmethoxy)carbamido]hydropyrimidinyl}acetamide

Guidance literature:: With 4-methyl-morpholine; hydrogenchloride; In tetrahydrofuran; argon;

Reference yield:

: 42826-42-6
pivalohydrazide

: 293329-65-4
N-[2-(5-tert-butyl-1,3,4-oxadiazol-2-yl)-1-(methylethyl)-2-oxoethyl]-2-{6-oxo-2-phenyl-5-[(phenylmethoxy)carbamido]hydropyrimidinyl}acetamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: 69 percent / p-toluenesulfonic acid monohydrate / 80 - 120 °C

2.1: n-BuLi; MgBr₂*OEt₂ / hexane / 1.5 h / -70 - -45 °C

2.2: 53 percent / hexane; tetrahydrofuran / -45 - -20 °C

3.1: 100 percent / HCl / dioxane / 2 h / 20 °C

4.1: 100 percent / HOBt*H₂O; EDC*HCl; N-methylmorpholine / dimethylformamide / 3.5 h / 20 °C

5.1: 100 percent / oxalyl chloride; DMSO / CH₂Cl₂ / 2 h / -70 °C

With 4-methyl-morpholine; hydrogenchloride; n-butyllithium; oxalyl dichloride; benzotriazol-1-ol; toluene-4-sulfonic acid; dimethyl sulfoxide; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; magnesium bromide; In 1,4-dioxane; hexane; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm000410y