4-acetyl-N,N-dibenzylbenzenesulfonamide

Base Information

• Chemical Name: 4-acetyl-N,N-dibenzylbenzenesulfonamide
• CAS No.: 259227-06-0
• Molecular Formula: C₂₂H₂₁NO₃S
• Molecular Weight: 379.48
• Mol file: 259227-06-0.mol

Synonyms:4-acetyl-N,N-dibenzylbenzenesulfonamide

Chemical Property of 4-acetyl-N,N-dibenzylbenzenesulfonamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-acetyl-N,N-dibenzylbenzenesulfonamide

There total 2 articles about 4-acetyl-N,N-dibenzylbenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-Acetylbenzenesulfonyl chloride (1788-10-9) + dibenzylamine (103-49-1) → 4-acetyl-N,N-dibenzylbenzenesulfonamide (259227-06-0)

Guidance literature:

With triethylamine; In tetrahydrofuran; at 20 ℃;

DOI:10.1021/jm991106b

Reference yield:

sodium 4-acetylbenzenesulfonate (61827-67-6) → 4-acetyl-N,N-dibenzylbenzenesulfonamide (259227-06-0)

Guidance literature:

Multi-step reaction with 2 steps

1: POCl₃ / 3 h / Heating

2: Et₃N / tetrahydrofuran / 20 °C

With triethylamine; trichlorophosphate; In tetrahydrofuran; 1: Chlorination / 2: sulfonylation;

DOI:10.1021/jm991106b

Reference yield: 86.0%

4-acetyl-N,N-dibenzylbenzenesulfonamide (259227-06-0) → N,N-dibenzyl-4-(2-bromoacetyl)benzenesulfonamide (259227-07-1)

Guidance literature:

With bromine; In chloroform; at 20 ℃; for 0.833333h;

upstream raw materials:

4-Acetylbenzenesulfonyl chloride

dibenzylamine

sodium 4-acetylbenzenesulfonate

Downstream raw materials:

N,N-dibenzyl-4-(2-bromoacetyl)benzenesulfonamide

4-[3-(4-fluorophenyl)-2,3-dihydro-2-oxo-4-oxazolyl]benzenesulfonamide