259227-07-1

Upstream product

• 61827-67-6 sodium 4-acetylbenzenesulfonate 
• 259227-06-0 4-acetyl-N,N-dibenzylbenzenesulfonamide 
• 1788-10-9 4-Acetylbenzenesulfonyl chloride 

Downstream Products

• 259227-08-2 N,N-dibenzyl-4-(2-hydroxyacetyl)benzenesulfonamide 
• 197240-09-8 4-[3-(4-fluorophenyl)-2,3-dihydro-2-oxo-4-oxazolyl]benzenesulfonamide 
• 259227-09-3 N,N-dibenzyl-4-(2-oxo-3-phenyl-2,3-dihydrooxazol-4-yl)benzenesulfonamide 
• 221218-60-6 phenyl-carbamic acid 2-(4-dibenzylsulfamoyl-phenyl)-2-oxo-ethyl ester 
• 259227-16-2 N,N-dibenzyl-4-[3-(2-methylphenyl)-2-oxo-2,3-dihydrooxazol-4-yl]benzenesulfonamide 

Relevant academic research and scientific papers

SUBSTITUTED THIAZOLE DERIVATIVES BEARING 3-PYRIDYL GROUPS, PROCESS FOR PREPARING THE SAME AND USE THEREOF

The present invention provides a pharmaceutical composition having a steroid C17,20-lyase inhibitory activity, which is useful as a prophylactic or therapeutic agent of prostatism, tumor such as breast cancer and the like, more particularly, a steroid C17,20-lyase inhibitor containing a compound represented by the formula: wherein A1 is an aromatic hydrocarbon group optionally having substituents or a heterocyclic group optionally having substituents, one of A2 and A3 is a hydrogen atom, a halogen atom, a C1-4 aliphatic hydrocarbon group optionally having substituents or an optionally esterified carboxyl group, the other of A2 and A3 is an aromatic hydrocarbon group optionally having substituents or a heterocyclic group optionally having substituents, and at least one of A1, A2 and A3 is a 3-pyridyl group optionally having substituents, or a salt thereof or a prodrug thereof.

Synthesis and biological evaluation of 3,4-diaryloxazolones: A new class of orally active cyclooxygenase-2 inhibitors

A series of 3,4-diaryloxazolones were prepared and evaluated for their ability to inhibit cyclooxygenase-2 (COX-2). Extensive structure-activity relationship work was carried out within this series, and a number of potent and selective COX-2 inhibitors we