3β-[(tert-butyldiphenylsilyl)oxy]-17,17-(ethylenedioxy)-androst-5-en-7-one

Base Information

Chemical Name:3β-[(tert-butyldiphenylsilyl)oxy]-17,17-(ethylenedioxy)-androst-5-en-7-one
CAS No.:537674-08-1
Molecular Formula:C₃₇H₄₈O₄Si
Molecular Weight:584.871
Hs Code.:

Synonyms:3β-[(tert-butyldiphenylsilyl)oxy]-17,17-(ethylenedioxy)-androst-5-en-7-one

Suppliers and Price of 3β-[(tert-butyldiphenylsilyl)oxy]-17,17-(ethylenedioxy)-androst-5-en-7-one

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 3β-[(tert-butyldiphenylsilyl)oxy]-17,17-(ethylenedioxy)-androst-5-en-7-one

Chemical Property:

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Technology Process of 3β-[(tert-butyldiphenylsilyl)oxy]-17,17-(ethylenedioxy)-androst-5-en-7-one

There total 2 articles about 3β-[(tert-butyldiphenylsilyl)oxy]-17,17-(ethylenedioxy)-androst-5-en-7-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 537674-07-0
3β-[(tert-butyldiphenylsilyl)oxy]-17,17-(ethylenedioxy)-androst-5-ene

: 537674-08-1
3β-[(tert-butyldiphenylsilyl)oxy]-17,17-(ethylenedioxy)-androst-5-en-7-one

Guidance literature:: With 1,3-dimethyl-1H-pyrazole; chromium(VI) oxide; In dichloromethane; at -20 ℃; for 4h;
DOI:10.1016/S0040-4020(03)00108-X

Reference yield:

: 58479-61-1
tert-butylchlorodiphenylsilane

: 537674-08-1
3β-[(tert-butyldiphenylsilyl)oxy]-17,17-(ethylenedioxy)-androst-5-en-7-one

Guidance literature:: Multi-step reaction with 3 steps

1: 95 percent / 1,8-diazabicyclo[5.4.0]undec-7-ene / CH₂Cl₂ / 2 h / 20 °C

2: 100 percent / triethyl orthoformate; p-TsOH*H₂O / CH₂Cl₂ / 20 °C

3: 81 percent / CrO₃; dimethylpyrazole / CH₂Cl₂ / 4 h / -20 °C

With 1,3-dimethyl-1H-pyrazole; chromium(VI) oxide; toluene-4-sulfonic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; orthoformic acid triethyl ester; In dichloromethane;
DOI:10.1016/S0040-4020(03)00108-X

Reference yield: 81.0%

: 537674-08-1
3β-[(tert-butyldiphenylsilyl)oxy]-17,17-(ethylenedioxy)-androst-5-en-7-one

: 537674-09-2
3β-[(tert-butyldiphenylsilyl)oxy]-17,17-(ethylenedioxy)-androst-5-en-β7-ol

Guidance literature:: With sodium tetrahydroborate; cerium(III) chloride; In tetrahydrofuran; ethanol; at 20 ℃; for 1h;
DOI:10.1016/S0040-4020(03)00108-X