537674-07-0

Upstream product

• 107-21-1 ethylene glycol 
• 191677-71-1 (3S,10R,13S)-3-((tert-butyldiphenylsilyl)oxy)-10,13-dimethyl-3,4,7,8,9,10,11,12,13,14,15,16-dodecahydro-1H-cyclopenta[a]phenanthren-17(2H)-one 
• 58479-61-1 tert-butylchlorodiphenylsilane 

Downstream Products

• 537674-17-2 6α,7β-(diacetoxy)-3β-[(tert-butyldiphenylsilyl)oxy]-5α-23,24-bisnorchol-16-en-22-ol 
• 537674-16-1 (Z)-6α,7β-(diacetoxy)-3β-[(tert-butyldiphenylsilyl)oxy]-5α-pregn-17(20)-ene 
• 537674-11-6 3β-[(tert-butyldiphenylsilyl)oxy]-17,17-(ethylenedioxy)-5α-androstan-6α,7β-diol 
• 537674-18-3 3-β-[(tert-butyldiphenylsilyl)oxy]-5α-23,24-bisnorchol-16-en-6α,7β,22-triol 
• 537674-14-9 (Z)-3β-[(tert-butyldiphenylsilyl)oxy]-6α,7β-[(methylethylidene)-bis-oxy]-5α-pregn-17(20)-ene 
• 537674-10-5 3β-[(tert-butyldiphenylsilyl)oxy]-17,17-(ethylenedioxy)-7β-acetoxy-androst-5-ene 
• 537674-12-7 3β-[(tert-butyldiphenylsilyl)oxy]-5α-androstan-6α,7β-diol-17-one 
• 537674-09-2 3β-[(tert-butyldiphenylsilyl)oxy]-17,17-(ethylenedioxy)-androst-5-en-β7-ol 
• 537674-13-8 (2S,4aR,4bS,6aS,9aS,9bR,9cR,12aR,12bS)-2-((tert-butyldiphenylsilyl)oxy)-4a,6a,11,11-tetramethyltetradecahydro-1H-cyclopenta[1,2]phenanthro[9,10-d][1,3]dioxol-7(8H)-one 
• 537674-08-1 3β-[(tert-butyldiphenylsilyl)oxy]-17,17-(ethylenedioxy)-androst-5-en-7-one 

Relevant academic research and scientific papers

Synthesis of a transmembrane ionophore based on a C2-symmetric polyhydroxysteroid derivative

The synthesis of the C2-symmetric bis-(20S)-5α-23,24-bisnorchol-16-en-3β,6α,7β-triol-22- terephthaloate (1), active as Na+-transporting transmembrane channel, has been achieved in 16 steps (10% overall yield) starting from the commercially available androst-5-en-3β-ol-17-one (3). The straightforward stereospecific functionalization of the side-chain, via the 'ene' reaction, and the successful regioselective terephthaloylation of the C-22 hydroxy group, illustrate the efficiency of the synthetic strategy.