Technology Process of (1R)-2-(4-tert-butoxyphenyl)-3-formyl-cyclopropanecarboxylic acid (2,4-dimethoxybenzyl)-methyl amide
There total 7 articles about (1R)-2-(4-tert-butoxyphenyl)-3-formyl-cyclopropanecarboxylic acid (2,4-dimethoxybenzyl)-methyl amide which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
tetrapropylammonium perruthennate; 4-methylmorpholine N-oxide;
In
dichloromethane;
at 20 ℃;
for 1h;
DOI:10.1021/ja011746f
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: magnesium / tetrahydrofuran / 5 h / Heating
1.2: 96 percent / iodine / tetrahydrofuran; diethyl ether / 0.5 h / 0 °C
2.1: 92 percent / copper iodide; pyrrolidine / palladium tetrakistriphenylphosphine / tetrahydrofuran / 36 h
3.1: 93 percent / quinoline; H2 / Pd/CaCO3; Pb(OAc)4 / diethyl ether / 0.5 h / 760.05 Torr
4.1: N,N-dimethylaniline / acetonitrile / 0.42 h / -10 °C
4.2: 83 percent / Et3N; H2O / acetonitrile
5.1: Rh2(S-MEPY)4 / CH2Cl2 / 37 h
6.1: AlMe3 / hexane; benzene / 1 h / 10 °C
6.2: 67 percent / benzene / 14 h / 50 °C
7.1: 89 percent / N-methylmorpholine-N-oxide; tetrapropylammonium-perruthenate / CH2Cl2 / 1 h / 20 °C
With
pyrrolidine; quinoline; copper(l) iodide; tetrapropylammonium perruthennate; Rh2[(2S)-5-hydroxypyrrolidine-2-COOMe]4; hydrogen; trimethylaluminum; magnesium; N,N-dimethyl-aniline; 4-methylmorpholine N-oxide;
lead(IV) acetate; Lindlar's catalyst; tetrakis(triphenylphosphine) palladium(0);
In
tetrahydrofuran; diethyl ether; hexane; dichloromethane; acetonitrile; benzene;
DOI:10.1021/ja011746f
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: 92 percent / copper iodide; pyrrolidine / palladium tetrakistriphenylphosphine / tetrahydrofuran / 36 h
2.1: 93 percent / quinoline; H2 / Pd/CaCO3; Pb(OAc)4 / diethyl ether / 0.5 h / 760.05 Torr
3.1: N,N-dimethylaniline / acetonitrile / 0.42 h / -10 °C
3.2: 83 percent / Et3N; H2O / acetonitrile
4.1: Rh2(S-MEPY)4 / CH2Cl2 / 37 h
5.1: AlMe3 / hexane; benzene / 1 h / 10 °C
5.2: 67 percent / benzene / 14 h / 50 °C
6.1: 89 percent / N-methylmorpholine-N-oxide; tetrapropylammonium-perruthenate / CH2Cl2 / 1 h / 20 °C
With
pyrrolidine; quinoline; copper(l) iodide; tetrapropylammonium perruthennate; Rh2[(2S)-5-hydroxypyrrolidine-2-COOMe]4; hydrogen; trimethylaluminum; N,N-dimethyl-aniline; 4-methylmorpholine N-oxide;
lead(IV) acetate; Lindlar's catalyst; tetrakis(triphenylphosphine) palladium(0);
In
tetrahydrofuran; diethyl ether; hexane; dichloromethane; acetonitrile; benzene;
DOI:10.1021/ja011746f
