60876-70-2

Basic information

• Product Name: 1-BROMO-4-TERT-BUTOXYBENZENE
• Synonyms: 1-BROMO-4-TERT-BUTOXYBENZENE;4-tert-Butoxybromobenzene;n-Butyl-(4-bromo)phenyl ether;4-Bromophenyl tert-butyl ether;p-Bromophenyl tert-butyl ether;p-tert-Butoxybromobenzene;1-Bromo-4-(tert-butoxy)benzene98%
• CAS NO: 60876-70-2
• Molecular Formula: C₁₀H₁₃BrO
• Molecular Weight: 229.11
• EINECS: -0
• Mol File: 60876-70-2.mol
• Article Data: 9

Chemical Properties

• Melting Point: 32-33°C
• Boiling Point: 63-65°C 0,4mm
• Flash Point: 63-65°C/0.4mm
• Appearance: /
• Density: 1.278g/cm³
• Vapor Pressure: 0.0329mmHg at 25°C
• Refractive Index: 1.5280
• Storage Temp.: Refrigerated.
• Water Solubility: Not miscible or difficult to mix in water.
• BRN: 2516411
• CAS DataBase Reference: 1-BROMO-4-TERT-BUTOXYBENZENE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-BROMO-4-TERT-BUTOXYBENZENE(60876-70-2)
• EPA Substance Registry System: 1-BROMO-4-TERT-BUTOXYBENZENE(60876-70-2)

Safety Data

• Hazard Codes: Xi,N,Xn
• Statements: 36/38-50/53-22
• Safety Statements: 26-36/37/39-61-60
• RIDADR: UN 3077 9 / PGIII
• HazardClass: IRRITANT
• Hazardous Substances Data: 60876-70-2(Hazardous Substances Data)

Usage

Chemical Properties

Light yellow liquid

Uses

It is used in the stereoselective synthesis of four stereoisomers of β-Methoxytyrosine, a component of callipeltin A.

InChI:InChI=1/C10H13BrO/c1-10(2,3)12-9-6-4-8(11)5-7-9/h4-7H,1-3H3

Upstream product

• 614-45-9 tert-Butyl peroxybenzoate 
• 18620-02-5 (4-bromophenyl)magnesium bromide 
• 6669-13-2 t-butyl phenyl ether 
• 106-41-2 4-bromo-phenol 
• 98946-18-0 tert-Butyl 2,2,2-trichloroacetimidate 
• 24424-99-5 di-tert-butyl dicarbonate 
• 115-11-7 isobutene 

Downstream Products

• 329318-60-7 1-(tert-butoxy)-4-iodobenzene 
• 808142-44-1 2-(4-tert-butoxyphenyl)thiophene 
• 857083-09-1 (4S)-3-{(2E)-3-[(tert-butoxy)phenyl]prop-2-enoyl}-4-phenyl-1,3-oxazolidin-2-one 
• 21323-98-8 3-(4-tert-butoxyphenyl)-propionic acid 
• 106-41-2 4-bromo-phenol 
• 727716-46-3 3-(4-tert-butoxyphenyl)propionic acid benzyl ester 
• 397883-81-7 (2R)-2-(4-hydroxybenzyl)-N-methyl-succinamic acid benzyl ester 
• 326473-10-3 3-(4-tert-butoxyphenyl)-2Z-propen-1-ol 
• 397883-53-3 3-(4-tert-butoxyphenyl)-prop-2-yne-1-ol 
• 326473-11-4 3-(4-tert-butoxyphenyl)-2Z-propenyl diazoacetate 
• 326473-12-5 (1R)-6-(4-tert-butoxyphenyl)-3-oxabicyclo[3.1.0]hexan-2-one 
• 326473-14-7 (1R)-2-(4-tert-butoxyphenyl)-3-formyl-cyclopropanecarboxylic acid dimethyl amide 
• 326473-15-8 (1R)-2-(4-hydroxyphenyl)-3-methylcarbamoyl-cyclopropanecarboxylic acid 
• 326473-20-5 (2R)-2-(4-hydroxybenzyl)-N-methyl-succinamic acid 

Relevant articles and documents

Preparation method of p-(2-methoxyl)ethyl phenol

The invention discloses a preparation method of p-(2-methoxyl) ethyl phenol. According to the preparation method, p-chlorophenol is taken as the raw material, after etherification reactions, p-chlorophenol with a protected phenolic hydroxyl group is obtained, and after Grignard reactions, chlorination reactions, and methoxyl substitution reactions, p-(2-methoxyl)ethyl phenol is generated. The provided preparation method has the advantages of easily available raw materials, mild reaction conditions, high safety coefficient, strong operability, simple technology, easy industrialization, high product purity, and stable quality. The prepared p-(2-methoxyl)ethyl phenol totally meets the using requirements of medical intermediates.

Examination of phosphoryl-mimicking functionalities within a macrocyclic Grb2 SH2 domain-binding platform

Reported herein are the design, synthesis, and Grb2 SH2 domain-binding affinities of several phosphoryl-mimicking groups displayed within the context of a conformationally constrained macrocyclic platform. With use of surface plasmon resonance techniques, single-digit nanomolar affinities were exhibited by phosphonic acid and malonyl-containing diacidic phosphoryl mimetics (for 4h and 4g, KD = 1.47 and 3.62 nM, respectively). Analogues containing monoacidic phosphoryl mimetics provided affinities of KD = 16-67 nM. Neutral phosphoryl-mimicking groups did not show appreciable binding.

Synthesis of chiral calix[n]arenes. Part 2: Synthesis of new chiral calix[n]arenes based on (p-hydroxy-phenyl)-menthone

The synthesis of new chiral calix[n]arenes, related to Corey's phenyl- menthol, is described. Starting from enantiomerically pure (R)-(+)-pulegone, calix[n]arenes with different ring sizes could be obtained in reasonable yield.