Toluene-4-sulfonic acid 5-[(1R,5S,7R)-8-benzyl-4-oxo-7-triisopropylsilanyloxymethyl-3,8-diaza-bicyclo[3.2.1]oct-(2Z)-ylidenemethyl]-2,4-dimethoxy-3-methyl-phenyl ester

Base Information

Chemical Name:Toluene-4-sulfonic acid 5-[(1R,5S,7R)-8-benzyl-4-oxo-7-triisopropylsilanyloxymethyl-3,8-diaza-bicyclo[3.2.1]oct-(2Z)-ylidenemethyl]-2,4-dimethoxy-3-methyl-phenyl ester
CAS No.:641627-90-9
Molecular Formula:C₄₀H₅₄N₂O₇SSi
Molecular Weight:735.029
Hs Code.:

Toluene-4-sulfonic acid 5-[(1R,5S,7R)-8-benzyl-4-oxo-7-triisopropylsilanyloxymethyl-3,8-diaza-bicyclo[3.2.1]oct-(2Z)-ylidenemethyl]-2,4-dimethoxy-3-methyl-phenyl ester

Synonyms:Toluene-4-sulfonic acid 5-[(1R,5S,7R)-8-benzyl-4-oxo-7-triisopropylsilanyloxymethyl-3,8-diaza-bicyclo[3.2.1]oct-(2Z)-ylidenemethyl]-2,4-dimethoxy-3-methyl-phenyl ester

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Chemical Property of Toluene-4-sulfonic acid 5-[(1R,5S,7R)-8-benzyl-4-oxo-7-triisopropylsilanyloxymethyl-3,8-diaza-bicyclo[3.2.1]oct-(2Z)-ylidenemethyl]-2,4-dimethoxy-3-methyl-phenyl ester

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Technology Process of Toluene-4-sulfonic acid 5-[(1R,5S,7R)-8-benzyl-4-oxo-7-triisopropylsilanyloxymethyl-3,8-diaza-bicyclo[3.2.1]oct-(2Z)-ylidenemethyl]-2,4-dimethoxy-3-methyl-phenyl ester

There total 8 articles about Toluene-4-sulfonic acid 5-[(1R,5S,7R)-8-benzyl-4-oxo-7-triisopropylsilanyloxymethyl-3,8-diaza-bicyclo[3.2.1]oct-(2Z)-ylidenemethyl]-2,4-dimethoxy-3-methyl-phenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 641627-84-1
toluene-4-sulfonic acid 2,4-dimethoxy-3-methyl-5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl ester

: 641627-89-6
(1S,5R,6R)-8-Benzyl-4-[1-iodo-meth-(Z)-ylidene]-6-triisopropylsilanyloxymethyl-3,8-diaza-bicyclo[3.2.1]octan-2-one

: 641627-90-9
Toluene-4-sulfonic acid 5-[(1R,5S,7R)-8-benzyl-4-oxo-7-triisopropylsilanyloxymethyl-3,8-diaza-bicyclo[3.2.1]oct-(2Z)-ylidenemethyl]-2,4-dimethoxy-3-methyl-phenyl ester

Guidance literature:: With methanol; tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In benzene; at 70 ℃; for 3.5h;
DOI:10.1021/ja039223q

Reference yield:

: 19676-67-6
2,4-dimethoxy-3-methylphenol

: 641627-90-9
Toluene-4-sulfonic acid 5-[(1R,5S,7R)-8-benzyl-4-oxo-7-triisopropylsilanyloxymethyl-3,8-diaza-bicyclo[3.2.1]oct-(2Z)-ylidenemethyl]-2,4-dimethoxy-3-methyl-phenyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: 96 percent / Et₃N / CH₂Cl₂ / 3.5 h / 20 °C

2.1: 84 percent / N-bromocussinimide / acetonitrile / 10.5 h

3.1: n-BuLi / diethyl ether; hexane / 0.33 h / -78 °C

3.2: 84 percent / diethyl ether / 0.33 h / -78 - -40 °C

4.1: MeOH; aq. K₂CO₃; Pd(PPh₃)4 / benzene / 3.5 h / 70 °C

With methanol; N-Bromosuccinimide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; n-butyllithium; potassium carbonate; triethylamine; In diethyl ether; hexane; dichloromethane; acetonitrile; benzene; 4.1: Suzuki coupling;
DOI:10.1021/ja039223q

Reference yield:

: 98-59-9
p-toluenesulfonyl chloride

: 641627-90-9
Toluene-4-sulfonic acid 5-[(1R,5S,7R)-8-benzyl-4-oxo-7-triisopropylsilanyloxymethyl-3,8-diaza-bicyclo[3.2.1]oct-(2Z)-ylidenemethyl]-2,4-dimethoxy-3-methyl-phenyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: 96 percent / Et₃N / CH₂Cl₂ / 3.5 h / 20 °C

2.1: 84 percent / N-bromocussinimide / acetonitrile / 10.5 h

3.1: n-BuLi / diethyl ether; hexane / 0.33 h / -78 °C

3.2: 84 percent / diethyl ether / 0.33 h / -78 - -40 °C

4.1: MeOH; aq. K₂CO₃; Pd(PPh₃)4 / benzene / 3.5 h / 70 °C

With methanol; N-Bromosuccinimide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; n-butyllithium; potassium carbonate; triethylamine; In diethyl ether; hexane; dichloromethane; acetonitrile; benzene; 4.1: Suzuki coupling;
DOI:10.1021/ja039223q