1-(2-(2-(2-(4-(1-aminoethyl)phenylamino)-5-(trifluoromethyl)pyrimidin-4-yl)ethyl)phenyl)cyclopropanecarboxamide

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Chemical Name:1-(2-(2-(2-(4-(1-aminoethyl)phenylamino)-5-(trifluoromethyl)pyrimidin-4-yl)ethyl)phenyl)cyclopropanecarboxamide
CAS No.:1566544-47-5
Molecular Formula:C₂₅H₂₆F₃N₅O
Molecular Weight:469.51
Hs Code.:

Synonyms:1-(2-(2-(2-(4-(1-aminoethyl)phenylamino)-5-(trifluoromethyl)pyrimidin-4-yl)ethyl)phenyl)cyclopropanecarboxamide

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Chemical Property of 1-(2-(2-(2-(4-(1-aminoethyl)phenylamino)-5-(trifluoromethyl)pyrimidin-4-yl)ethyl)phenyl)cyclopropanecarboxamide

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Technology Process of 1-(2-(2-(2-(4-(1-aminoethyl)phenylamino)-5-(trifluoromethyl)pyrimidin-4-yl)ethyl)phenyl)cyclopropanecarboxamide

There total 5 articles about 1-(2-(2-(2-(4-(1-aminoethyl)phenylamino)-5-(trifluoromethyl)pyrimidin-4-yl)ethyl)phenyl)cyclopropanecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 1566543-44-9
tert-butyl 1-(4-(4-(2-(1-carbamoylcyclopropyl)phenethyl)-5-(trifluoromethyl)pyrimidin-2-ylamino)phenyl)ethylcarbamate

: 1566544-47-5
1-(2-(2-(2-(4-(1-aminoethyl)phenylamino)-5-(trifluoromethyl)pyrimidin-4-yl)ethyl)phenyl)cyclopropanecarboxamide

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 16h;

Reference yield:

: 1566544-45-3
tert-butyl (1-(4-((4-chloro-5-(trifluoromethyl)pyrimidin-2-yl)amino)phenyl)ethyl)carbamate

: 1566544-47-5
1-(2-(2-(2-(4-(1-aminoethyl)phenylamino)-5-(trifluoromethyl)pyrimidin-4-yl)ethyl)phenyl)cyclopropanecarboxamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: bis-triphenylphosphine-palladium(II) chloride; Tetra(tert-butyl)phosphonium-tetrafluoroborat; copper(l) iodide / N,N-dimethyl-formamide / 0.17 h / Inert atmosphere

1.2: 0.25 h / 120 °C / Microwave irradiation

2.1: hydrogen; palladium 10% on activated carbon / N,N-dimethyl-formamide; ethyl acetate / 16 h / 20 °C

3.1: trifluoroacetic acid / dichloromethane / 16 h / 20 °C

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; palladium 10% on activated carbon; hydrogen; Tetra(tert-butyl)phosphonium-tetrafluoroborat; trifluoroacetic acid; In dichloromethane; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

: 1566544-46-4
tert-butyl 1-(4-(4-((2-(1-carbamoylcyclopropyl)phenyl)ethynyl)-5-(trifluoromethyl)pyrimidin-2-ylamino)phenyl)ethylcarbamate

: 1566544-47-5
1-(2-(2-(2-(4-(1-aminoethyl)phenylamino)-5-(trifluoromethyl)pyrimidin-4-yl)ethyl)phenyl)cyclopropanecarboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogen; palladium 10% on activated carbon / N,N-dimethyl-formamide; ethyl acetate / 16 h / 20 °C

2: trifluoroacetic acid / dichloromethane / 16 h / 20 °C

With palladium 10% on activated carbon; hydrogen; trifluoroacetic acid; In dichloromethane; ethyl acetate; N,N-dimethyl-formamide;