1,3-dibromo-2-chloro-5-methoxybenzene

Base Information

• Chemical Name: 1,3-dibromo-2-chloro-5-methoxybenzene
• CAS No.: 174913-47-4
• Molecular Formula: C₇H₅Br₂ClO
• Molecular Weight: 300.377
• Mol file: 174913-47-4.mol

Synonyms:1,3-dibromo-2-chloro-5-methoxybenzene

Chemical Property of 1,3-dibromo-2-chloro-5-methoxybenzene

Chemical Property:

Purity/Quality:

1,3-Dibromo-2-chloro-5-methoxybenzene 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1,3-dibromo-2-chloro-5-methoxybenzene

There total 9 articles about 1,3-dibromo-2-chloro-5-methoxybenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

3,5-dibromoanisole (74137-36-3) → 1,3-dibromo-2-chloro-5-methoxybenzene (174913-47-4)

Guidance literature:

With N-chloro-succinimide; In acetonitrile; at 86.9 ℃; for 40h;

Reference yield: 52.0%

2,6-dibromo-4-methoxyaniline (95970-05-1) → 1,3-dibromo-2-chloro-5-methoxybenzene (174913-47-4)

Guidance literature:

2,6-dibromo-4-methoxyaniline; With hydrogenchloride; sodium nitrite; at 0 ℃;

With copper(l) chloride; Further stages.;

DOI:10.1021/ja074778x

Reference yield:

4-chloro-phenol (106-48-9,82344-39-6) → 1,3-dibromo-2-chloro-5-methoxybenzene (174913-47-4)

Guidance literature:

Multi-step reaction with 5 steps

1: alkaline solution

2: nitric acid

3: tin; concentrated hydrochloric acid

4: glacial acetic acid; bromine / unter Kuehlung

5: alcohol; sulfuric acid / Diazotization

With hydrogenchloride; tin; ethanol; alkaline solution; sulfuric acid; bromine; nitric acid; acetic acid;

DOI:10.1017/S1092852900017430

upstream raw materials:

2,4-dibromo-3-chloro-6-methoxyaniline

2,6-dibromo-4-chlorophenol

dimethyl sulfate

4-chloromethoxybenzene

Downstream raw materials:

2,6-dibromo-4-chlorophenol

3,5-dibromo-4-chloro-2,6-dinitro-anisole

2-chloro-5-methoxy-1,3-bis-trimethylsilanylbenzene