Technology Process of (E)-2-(2-methoxy-5-(2-(2,4,6-trimethoxyphenyl)vinylsulfonamido)phenylamino)propanoic acid
There total 10 articles about (E)-2-(2-methoxy-5-(2-(2,4,6-trimethoxyphenyl)vinylsulfonamido)phenylamino)propanoic acid which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
sodium hydroxide;
In
ethanol; water;
at 60 ℃;
for 1h;
Inert atmosphere;
DOI:10.1021/jm400575x
- Guidance literature:
-
Multi-step reaction with 10 steps
1.1: potassium hydroxide / 0.5 h / 20 °C / Inert atmosphere
2.1: triethylamine / dichloromethane / 3 h / 20 °C / Inert atmosphere
3.1: sodium hydroxide / water / 3 h / 20 °C / Inert atmosphere
4.1: thionyl chloride / dichloromethane / 6 h / 20 °C / Inert atmosphere
5.1: aluminum (III) chloride / dichloromethane / 4 h / 20 °C / Inert atmosphere
6.1: sodium tetrahydroborate / tetrahydrofuran / 3 h / 0 - 20 °C / Inert atmosphere
7.1: toluene-4-sulfonic acid / toluene / 3 h / 20 - 120 °C / Inert atmosphere; Dean-Stark
8.1: sodium dithionite / water; acetone / 0.5 h / 50 °C / Inert atmosphere
9.1: sodium acetate / ethanol / 0.17 h / Reflux; Inert atmosphere
9.2: 48 h / Reflux
10.1: sodium hydroxide / water; ethanol / 1 h / 60 °C / Inert atmosphere
With
aluminum (III) chloride; sodium tetrahydroborate; thionyl chloride; sodium dithionite; sodium acetate; toluene-4-sulfonic acid; triethylamine; potassium hydroxide; sodium hydroxide;
In
tetrahydrofuran; ethanol; dichloromethane; water; acetone; toluene;
DOI:10.1021/jm400575x
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: sodium hydroxide / water / 3 h / 20 °C / Inert atmosphere
2.1: acetic acid; benzylamine / 8 h / 20 °C / Reflux; Inert atmosphere
3.1: sodium dithionite / water; acetone / 0.5 h / 50 °C / Inert atmosphere
4.1: sodium acetate / ethanol / 0.17 h / Reflux; Inert atmosphere
4.2: 48 h / Reflux
5.1: sodium hydroxide / water; ethanol / 1 h / 60 °C / Inert atmosphere
With
sodium dithionite; sodium acetate; acetic acid; benzylamine; sodium hydroxide;
In
ethanol; water; acetone;
DOI:10.1021/jm400575x
