(E)-methyl 2-(2-methoxy-5-(2-(2,4,6-trimethoxyphenyl)vinylsulfonamido)phenylamino)propanoate

Base Information

Chemical Name:(E)-methyl 2-(2-methoxy-5-(2-(2,4,6-trimethoxyphenyl)vinylsulfonamido)phenylamino)propanoate
CAS No.:1445726-84-0
Molecular Formula:C₂₂H₂₈N₂O₈S
Molecular Weight:480.539
Hs Code.:

Synonyms:(E)-methyl 2-(2-methoxy-5-(2-(2,4,6-trimethoxyphenyl)vinylsulfonamido)phenylamino)propanoate

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Chemical Property of (E)-methyl 2-(2-methoxy-5-(2-(2,4,6-trimethoxyphenyl)vinylsulfonamido)phenylamino)propanoate

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Technology Process of (E)-methyl 2-(2-methoxy-5-(2-(2,4,6-trimethoxyphenyl)vinylsulfonamido)phenylamino)propanoate

There total 9 articles about (E)-methyl 2-(2-methoxy-5-(2-(2,4,6-trimethoxyphenyl)vinylsulfonamido)phenylamino)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 5445-17-0
Methyl 2-bromopropionate

: 595582-49-3
(E)-N-(3-amino-4-methoxyphenyl)-2-(2,4,6-trimethoxyphenyl)ethenesulfonamide

: 1445726-84-0
(E)-methyl 2-(2-methoxy-5-(2-(2,4,6-trimethoxyphenyl)vinylsulfonamido)phenylamino)propanoate

Guidance literature:: Methyl 2-bromopropionate; With sodium acetate; In ethanol; for 0.166667h; Reflux; Inert atmosphere;

(E)-N-(3-amino-4-methoxyphenyl)-2-(2,4,6-trimethoxyphenyl)ethenesulfonamide; In ethanol; for 48h; Reflux;
DOI:10.1021/jm400575x

Reference yield:

: 1445726-97-5
ethyl 2-(N-(4-Methoxy-3-nitrophenyl)sulfamoyl)acetate

: 1445726-84-0
(E)-methyl 2-(2-methoxy-5-(2-(2,4,6-trimethoxyphenyl)vinylsulfonamido)phenylamino)propanoate

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydroxide / water / 3 h / 20 °C / Inert atmosphere

2.1: acetic acid; benzylamine / 8 h / 20 °C / Reflux; Inert atmosphere

3.1: sodium dithionite / water; acetone / 0.5 h / 50 °C / Inert atmosphere

4.1: sodium acetate / ethanol / 0.17 h / Reflux; Inert atmosphere

4.2: 48 h / Reflux

With sodium dithionite; sodium acetate; acetic acid; benzylamine; sodium hydroxide; In ethanol; water; acetone;
DOI:10.1021/jm400575x

Reference yield:

: 595582-47-1
2-(N-(4-methoxy-3-nitrophenyl)sulfamoyl)acetic acid

: 1445726-84-0
(E)-methyl 2-(2-methoxy-5-(2-(2,4,6-trimethoxyphenyl)vinylsulfonamido)phenylamino)propanoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: acetic acid; benzylamine / 8 h / 20 °C / Reflux; Inert atmosphere

2.1: sodium dithionite / water; acetone / 0.5 h / 50 °C / Inert atmosphere

3.1: sodium acetate / ethanol / 0.17 h / Reflux; Inert atmosphere

3.2: 48 h / Reflux

With sodium dithionite; sodium acetate; acetic acid; benzylamine; In ethanol; water; acetone;
DOI:10.1021/jm400575x