N-(4-(2-oxo-4-(4-(2-(piperidin-1-yl)ethoxy)phenyl)-2H-chromen-3-yl)phenyl)acetamide

Base Information

• Chemical Name: N-(4-(2-oxo-4-(4-(2-(piperidin-1-yl)ethoxy)phenyl)-2H-chromen-3-yl)phenyl)acetamide
• CAS No.: 1613152-66-1
• Molecular Formula: C₃₀H₃₀N₂O₄
• Molecular Weight: 482.579

Synonyms:N-(4-(2-oxo-4-(4-(2-(piperidin-1-yl)ethoxy)phenyl)-2H-chromen-3-yl)phenyl)acetamide

Chemical Property of N-(4-(2-oxo-4-(4-(2-(piperidin-1-yl)ethoxy)phenyl)-2H-chromen-3-yl)phenyl)acetamide

Chemical Property:

Purity/Quality:

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Technology Process of N-(4-(2-oxo-4-(4-(2-(piperidin-1-yl)ethoxy)phenyl)-2H-chromen-3-yl)phenyl)acetamide

There total 5 articles about N-(4-(2-oxo-4-(4-(2-(piperidin-1-yl)ethoxy)phenyl)-2H-chromen-3-yl)phenyl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

piperidine (110-89-4) + N-(4-(4-(4-(2-bromoethoxy)phenyl)-2-oxo-2H-chromen-3-yl)phenyl)acetamide (1613152-64-9) → N-(4-(2-oxo-4-(4-(2-(piperidin-1-yl)ethoxy)phenyl)-2H-chromen-3-yl)phenyl)acetamide (1613152-66-1)

Guidance literature:

With silver nitrate; In tetrahydrofuran; at 125 ℃; for 0.25h; Microwave irradiation; Sealed tube;

DOI:10.1016/j.bmcl.2014.04.106

Reference yield:

4-aminophenylacetic acid (1197-55-3) → N-(4-(2-oxo-4-(4-(2-(piperidin-1-yl)ethoxy)phenyl)-2H-chromen-3-yl)phenyl)acetamide (1613152-66-1)

Guidance literature:

Multi-step reaction with 4 steps

1: potassium carbonate / Reflux

2: boron tribromide / dichloromethane / 1 h

3: potassium carbonate / acetone / Reflux

4: silver nitrate / tetrahydrofuran / 0.25 h / 125 °C / Microwave irradiation; Sealed tube

With boron tribromide; potassium carbonate; silver nitrate; In tetrahydrofuran; dichloromethane; acetone; 1: |Perkin Coumarin Rearrangement;

DOI:10.1016/j.bmcl.2014.04.106

Reference yield:

(2-hydroxyphenyl)(4-methoxyphenyl)methanone (18733-07-8) → N-(4-(2-oxo-4-(4-(2-(piperidin-1-yl)ethoxy)phenyl)-2H-chromen-3-yl)phenyl)acetamide (1613152-66-1)

Guidance literature:

Multi-step reaction with 4 steps

1: potassium carbonate / Reflux

2: boron tribromide / dichloromethane / 1 h

3: potassium carbonate / acetone / Reflux

4: silver nitrate / tetrahydrofuran / 0.25 h / 125 °C / Microwave irradiation; Sealed tube

With boron tribromide; potassium carbonate; silver nitrate; In tetrahydrofuran; dichloromethane; acetone; 1: |Perkin Coumarin Rearrangement;

DOI:10.1016/j.bmcl.2014.04.106

upstream raw materials:

4-aminophenylacetic acid

(2-hydroxyphenyl)(4-methoxyphenyl)methanone

piperidine

N-(4-(4-(4-(2-bromoethoxy)phenyl)-2-oxo-2H-chromen-3-yl)phenyl)acetamide

Downstream raw materials:

N¹,N³-bis(4-(2-oxo-4-(4-(2-(piperidin-1-yl)ethoxy)phenyl)-2H-chromen-3-yl)phenyl)malonamide

N¹,N⁶-bis(4-(2-oxo-4-(4-(2-(piperidin-1-yl)ethoxy)phenyl)-2H-chromen-3-yl)phenyl)adipamide

N¹,N¹⁰-bis(4-(2-oxo-4-(4-(2-(piperidin-1-yl)ethoxy)phenyl)-2H-chromen-3-yl)phenyl)decanediamide

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