1-<4-<2-(tert-butyldimethylsilyloxy)ethyl>phenyl>-2,2,2-trifluoro-1-ethanone

Base Information

Chemical Name:1-<4-<2-(tert-butyldimethylsilyloxy)ethyl>phenyl>-2,2,2-trifluoro-1-ethanone
CAS No.:73899-16-8
Molecular Formula:C₁₆H₂₃F₃O₂Si
Molecular Weight:332.438
Hs Code.:

Synonyms:1-<4-<2-(tert-butyldimethylsilyloxy)ethyl>phenyl>-2,2,2-trifluoro-1-ethanone

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Chemical Property of 1-<4-<2-(tert-butyldimethylsilyloxy)ethyl>phenyl>-2,2,2-trifluoro-1-ethanone

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Technology Process of 1-<4-<2-(tert-butyldimethylsilyloxy)ethyl>phenyl>-2,2,2-trifluoro-1-ethanone

There total 3 articles about 1-<4-<2-(tert-butyldimethylsilyloxy)ethyl>phenyl>-2,2,2-trifluoro-1-ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 340-07-8
N-(trifluoroacetyl)piperidine

: 73899-15-7
1-(t-butyldimethylsilyloxy)-2-(4-bromophenyl)ethane

: 73899-16-8
1-<4-<2-(tert-butyldimethylsilyloxy)ethyl>phenyl>-2,2,2-trifluoro-1-ethanone

Guidance literature:: 1-(t-butyldimethylsilyloxy)-2-(4-bromophenyl)ethane; With n-butyllithium; In diethyl ether; hexane; at -55 - 0 ℃; for 2h;

N-(trifluoroacetyl)piperidine; In diethyl ether; hexane; at -50 ℃; for 3h;
DOI:10.1021/tx9501602

Reference yield:

: 4654-39-1
4-bromophenethanol

: 73899-16-8
1-<4-<2-(tert-butyldimethylsilyloxy)ethyl>phenyl>-2,2,2-trifluoro-1-ethanone

Guidance literature:: Multi-step reaction with 2 steps

1.1: 89 percent / DMAP; Et₃N / CH₂Cl₂

2.1: n-BuLi / diethyl ether; hexane / 2 h / -55 - 0 °C

2.2: 96 percent / diethyl ether; hexane / 3 h / -50 °C

With dmap; n-butyllithium; triethylamine; In diethyl ether; hexane; dichloromethane; 1.1: Condensation / 2.1: Metallation / 2.2: Substitution;
DOI:10.1021/tx9501602

Reference yield:

: 18162-48-6
tert-butyldimethylsilyl chloride

: 73899-16-8
1-<4-<2-(tert-butyldimethylsilyloxy)ethyl>phenyl>-2,2,2-trifluoro-1-ethanone

Guidance literature:: Multi-step reaction with 2 steps

1.1: 89 percent / DMAP; Et₃N / CH₂Cl₂

2.1: n-BuLi / diethyl ether; hexane / 2 h / -55 - 0 °C

2.2: 96 percent / diethyl ether; hexane / 3 h / -50 °C

With dmap; n-butyllithium; triethylamine; In diethyl ether; hexane; dichloromethane; 1.1: Condensation / 2.1: Metallation / 2.2: Substitution;
DOI:10.1021/tx9501602