N-[2-[[hydroxy[2-phenyl-1-[[(phenylmethoxy)carbonyl]amino]ethyl]phosphinyl]methyl]-1-oxo-3-phenylpropyl]-L-alanine

Base Information

Chemical Name:N-[2-[[hydroxy[2-phenyl-1-[[(phenylmethoxy)carbonyl]amino]ethyl]phosphinyl]methyl]-1-oxo-3-phenylpropyl]-L-alanine
CAS No.:207286-75-7
Molecular Formula:C₂₉H₃₃N₂O₇P
Molecular Weight:552.564
Hs Code.:

Synonyms:N-[2-[[hydroxy[2-phenyl-1-[[(phenylmethoxy)carbonyl]amino]ethyl]phosphinyl]methyl]-1-oxo-3-phenylpropyl]-L-alanine

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Chemical Property of N-[2-[[hydroxy[2-phenyl-1-[[(phenylmethoxy)carbonyl]amino]ethyl]phosphinyl]methyl]-1-oxo-3-phenylpropyl]-L-alanine

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Technology Process of N-[2-[[hydroxy[2-phenyl-1-[[(phenylmethoxy)carbonyl]amino]ethyl]phosphinyl]methyl]-1-oxo-3-phenylpropyl]-L-alanine

There total 6 articles about N-[2-[[hydroxy[2-phenyl-1-[[(phenylmethoxy)carbonyl]amino]ethyl]phosphinyl]methyl]-1-oxo-3-phenylpropyl]-L-alanine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.4%

: 207286-74-6
Phenylmethyl N-[2-[[hydroxy[2-phenyl-1-[[(phenylmethoxy)carbonyl]amino]ethyl]phosphinyl]methyl]-1-oxo-3-phenylpropyl]-L-alaninate

: 207286-75-7
N-[2-[[hydroxy[2-phenyl-1-[[(phenylmethoxy)carbonyl]amino]ethyl]phosphinyl]methyl]-1-oxo-3-phenylpropyl]-L-alanine

Guidance literature:

Reference yield:

: (S)-2-{2-Benzyl-3-[(1-benzyloxycarbonylamino-2-phenyl-ethyl)-hydroxy-phosphinoyl]-propionylamino}-propionic acid methyl ester

: 207286-75-7
N-[2-[[hydroxy[2-phenyl-1-[[(phenylmethoxy)carbonyl]amino]ethyl]phosphinyl]methyl]-1-oxo-3-phenylpropyl]-L-alanine

Guidance literature:: With lithium hydroxide; In ethanol; at 20 ℃; for 8h;
DOI:10.1021/jm990483l

Reference yield:

: 20593-63-9
2-Benzylacrylic acid ethyl ester

: 207286-75-7
N-[2-[[hydroxy[2-phenyl-1-[[(phenylmethoxy)carbonyl]amino]ethyl]phosphinyl]methyl]-1-oxo-3-phenylpropyl]-L-alanine

Guidance literature:: Multi-step reaction with 4 steps

1: 67 percent / N,O-bistrimethylsilylacetamide

2: 100 percent / 1 M aq. NaOH / ethanol / 20 °C

3: Et₃N; BOP / dimethylformamide / 0.5 h / 20 °C

4: 1 M aq. LiOH / ethanol / 8 h / 20 °C

With lithium hydroxide; sodium hydroxide; N,O-bis-(trimethylsilyl)-acetamide; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; In ethanol; N,N-dimethyl-formamide; 1: Addition / 2: Hydrolysis / 3: Acylation / 4: Hydrolysis;
DOI:10.1021/jm990483l