3-[hydroxy[2-phenyl-1-[[(phenylmethoxy)carbonyl]amino]ethyl]phosphinyl]-2-(phenylmethyl)propanoic acid

Base Information

• Chemical Name: 3-[hydroxy[2-phenyl-1-[[(phenylmethoxy)carbonyl]amino]ethyl]phosphinyl]-2-(phenylmethyl)propanoic acid
• CAS No.: 207286-71-3
• Molecular Formula: C₂₆H₂₈NO₆P
• Molecular Weight: 481.485

Synonyms:3-[hydroxy[2-phenyl-1-[[(phenylmethoxy)carbonyl]amino]ethyl]phosphinyl]-2-(phenylmethyl)propanoic acid

Chemical Property of 3-[hydroxy[2-phenyl-1-[[(phenylmethoxy)carbonyl]amino]ethyl]phosphinyl]-2-(phenylmethyl)propanoic acid

Chemical Property:

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Technology Process of 3-[hydroxy[2-phenyl-1-[[(phenylmethoxy)carbonyl]amino]ethyl]phosphinyl]-2-(phenylmethyl)propanoic acid

There total 4 articles about 3-[hydroxy[2-phenyl-1-[[(phenylmethoxy)carbonyl]amino]ethyl]phosphinyl]-2-(phenylmethyl)propanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

Methyl 3-[hydroxy[2-phenyl-1-[[(phenylmethoxy)carbonyl]amino]ethyl]phosphinyl]-2-(phenylmethyl)propanoate (142178-56-1) → 3-[hydroxy[2-phenyl-1-[[(phenylmethoxy)carbonyl]amino]ethyl]phosphinyl]-2-(phenylmethyl)propanoic acid (207286-71-3)

Guidance literature:

With sodium hydroxide; In methanol;

Reference yield:

[2-phenyl-1-[[(phenylmethoxy)carbonyl]amino]ethyl]phosphinic acid (115961-49-4) → 3-[hydroxy[2-phenyl-1-[[(phenylmethoxy)carbonyl]amino]ethyl]phosphinyl]-2-(phenylmethyl)propanoic acid (207286-71-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 67 percent / N,O-bistrimethylsilylacetamide

2: 100 percent / 1 M aq. NaOH / ethanol / 20 °C

With sodium hydroxide; N,O-bis-(trimethylsilyl)-acetamide; In ethanol; 1: Addition / 2: Hydrolysis;

DOI:10.1021/jm990483l

Reference yield:

2-Benzylacrylic acid ethyl ester (20593-63-9) → 3-[hydroxy[2-phenyl-1-[[(phenylmethoxy)carbonyl]amino]ethyl]phosphinyl]-2-(phenylmethyl)propanoic acid (207286-71-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 67 percent / N,O-bistrimethylsilylacetamide

2: 100 percent / 1 M aq. NaOH / ethanol / 20 °C

With sodium hydroxide; N,O-bis-(trimethylsilyl)-acetamide; In ethanol; 1: Addition / 2: Hydrolysis;

DOI:10.1021/jm990483l

upstream raw materials:

Methyl 3-[hydroxy[2-phenyl-1-[[(phenylmethoxy)carbonyl]amino]ethyl]phosphinyl]-2-(phenylmethyl)propanoate

2-Benzylacrylic acid ethyl ester

[2-phenyl-1-[[(phenylmethoxy)carbonyl]amino]ethyl]phosphinic acid

methyl 2-benzylacrylate

Downstream raw materials:

(S)-2-{2-Benzyl-3-[(1-benzyloxycarbonylamino-2-phenyl-ethyl)-hydroxy-phosphinoyl]-propionylamino}-3-phenyl-propionic acid methyl ester

Phenylmethyl N-[2-[[hydroxy[2-phenyl-1-[[(phenylmethoxy)carbonyl]amino]ethyl]phosphinyl]methyl]-1-oxo-3-phenylpropyl]-L-alaninate

DL-alanine benzyl ester

(S)-2-{2-Benzyl-3-[(1-benzyloxycarbonylamino-2-phenyl-ethyl)-hydroxy-phosphinoyl]-propionylamino}-3-biphenyl-4-yl-propionic acid

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