butyl-ethyl-[3-(4-isopropyl-2-methylsulfanyl-phenyl)-5-methyl-3H-[1,2,3]triazolo[4,5-b]pyridin-7-yl]-amine

Base Information

• Chemical Name: butyl-ethyl-[3-(4-isopropyl-2-methylsulfanyl-phenyl)-5-methyl-3H-[1,2,3]triazolo[4,5-b]pyridin-7-yl]-amine
• CAS No.: 220953-62-8
• Molecular Formula: C₂₂H₃₁N₅S
• Molecular Weight: 397.588

Synonyms:butyl-ethyl-[3-(4-isopropyl-2-methylsulfanyl-phenyl)-5-methyl-3H-[1,2,3]triazolo[4,5-b]pyridin-7-yl]-amine

Chemical Property of butyl-ethyl-[3-(4-isopropyl-2-methylsulfanyl-phenyl)-5-methyl-3H-[1,2,3]triazolo[4,5-b]pyridin-7-yl]-amine

Chemical Property:

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Technology Process of butyl-ethyl-[3-(4-isopropyl-2-methylsulfanyl-phenyl)-5-methyl-3H-[1,2,3]triazolo[4,5-b]pyridin-7-yl]-amine

There total 7 articles about butyl-ethyl-[3-(4-isopropyl-2-methylsulfanyl-phenyl)-5-methyl-3H-[1,2,3]triazolo[4,5-b]pyridin-7-yl]-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

3-amino-2--4-(N-butyl-N-ethylamino)-6-methylpyridine (220953-58-2) → butyl-ethyl-[3-(4-isopropyl-2-methylsulfanyl-phenyl)-5-methyl-3H-[1,2,3]triazolo[4,5-b]pyridin-7-yl]-amine (220953-62-8)

Guidance literature:

With acetic acid; sodium nitrite; In dichloromethane; at 25 ℃; for 2h;

DOI:10.1021/jm980224g

Reference yield:

4-hydroxy-6-methyl-3-nitro-2(1H)-pyridinone (4966-90-9) → butyl-ethyl-[3-(4-isopropyl-2-methylsulfanyl-phenyl)-5-methyl-3H-[1,2,3]triazolo[4,5-b]pyridin-7-yl]-amine (220953-62-8)

Guidance literature:

Multi-step reaction with 5 steps

1: POCl₃, diethylaniline / 3 h / Heating

2: 64 percent / N,N-diisopropylethylamine / 5 h / Heating

3: 65 percent / 140 °C

4: 62 percent / Na₂S₂O₄, NH₄OH / dioxane; H₂O / 25 °C

5: 81 percent / 50 percent aq. AcOH, NaNO₂ / CH₂Cl₂ / 2 h / 25 °C

With ammonium hydroxide; sodium dithionite; acetic acid; N-ethyl-N,N-diisopropylamine; N,N-diethylaniline; sodium nitrite; trichlorophosphate; In 1,4-dioxane; dichloromethane; water;

DOI:10.1021/jm980224g

Reference yield:

2,4-dichloro-6-methyl-3-nitropyridine (63897-12-1) → butyl-ethyl-[3-(4-isopropyl-2-methylsulfanyl-phenyl)-5-methyl-3H-[1,2,3]triazolo[4,5-b]pyridin-7-yl]-amine (220953-62-8)

Guidance literature:

Multi-step reaction with 4 steps

1: 64 percent / N,N-diisopropylethylamine / 5 h / Heating

2: 65 percent / 140 °C

3: 62 percent / Na₂S₂O₄, NH₄OH / dioxane; H₂O / 25 °C

4: 81 percent / 50 percent aq. AcOH, NaNO₂ / CH₂Cl₂ / 2 h / 25 °C

With ammonium hydroxide; sodium dithionite; acetic acid; N-ethyl-N,N-diisopropylamine; sodium nitrite; In 1,4-dioxane; dichloromethane; water;

DOI:10.1021/jm980224g

upstream raw materials:

3-amino-2--4-(N-butyl-N-ethylamino)-6-methylpyridine

4-hydroxy-6-methyl-3-nitro-2(1H)-pyridinone

2,4-dichloro-6-methyl-3-nitropyridine

2-iodo-4-isopropylaniline

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