methyl N-((2-amino-6-(benzyloxy)purin-9-yl)acetyl)-N-(2-Boc-aminoethyl)glycinate

Base Information

Chemical Name:methyl N-((2-amino-6-(benzyloxy)purin-9-yl)acetyl)-N-(2-Boc-aminoethyl)glycinate
CAS No.:158097-21-3
Molecular Formula:C₂₄H₃₁N₇O₆
Molecular Weight:513.553
Hs Code.:

Synonyms:methyl N-((2-amino-6-(benzyloxy)purin-9-yl)acetyl)-N-(2-Boc-aminoethyl)glycinate

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Chemical Property of methyl N-((2-amino-6-(benzyloxy)purin-9-yl)acetyl)-N-(2-Boc-aminoethyl)glycinate

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Technology Process of methyl N-((2-amino-6-(benzyloxy)purin-9-yl)acetyl)-N-(2-Boc-aminoethyl)glycinate

There total 4 articles about methyl N-((2-amino-6-(benzyloxy)purin-9-yl)acetyl)-N-(2-Boc-aminoethyl)glycinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

: 128421-86-3
methyl N-(2-(tert-butyloxycarbonyl)aminoethyl)glycinate

: 149411-94-9
2-(2-amino-6-(benzyloxy)-9H-purin-9-yl)acetic acid

: 158097-21-3
methyl N-((2-amino-6-(benzyloxy)purin-9-yl)acetyl)-N-(2-Boc-aminoethyl)glycinate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate; In N,N-dimethyl-formamide; for 4h;
DOI:10.1021/jo00098a042

Reference yield:

: 10310-21-1
2-Amino-6-chloropurin

: 158097-21-3
methyl N-((2-amino-6-(benzyloxy)purin-9-yl)acetyl)-N-(2-Boc-aminoethyl)glycinate

Guidance literature:: Multi-step reaction with 3 steps

1: 45 percent / K₂CO₃ / dimethylformamide / 20 h

2: 52 percent / Na / 1.) 130 deg C, 2 h, 2.) DMF, r.t., overnight

3: 63 percent / DIEA, bromotris(pyrrolidino)phosphonium hexafluorophosphate / dimethylformamide / 4 h

With sodium; potassium carbonate; N-ethyl-N,N-diisopropylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate; In N,N-dimethyl-formamide;
DOI:10.1021/jo00098a042

Reference yield:

: 149376-70-5
2-amino-6-chloro-9-carboxymethylpurine

: 158097-21-3
methyl N-((2-amino-6-(benzyloxy)purin-9-yl)acetyl)-N-(2-Boc-aminoethyl)glycinate

Guidance literature:: Multi-step reaction with 2 steps

1: 52 percent / Na / 1.) 130 deg C, 2 h, 2.) DMF, r.t., overnight

2: 63 percent / DIEA, bromotris(pyrrolidino)phosphonium hexafluorophosphate / dimethylformamide / 4 h

With sodium; N-ethyl-N,N-diisopropylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate; In N,N-dimethyl-formamide;
DOI:10.1021/jo00098a042